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Table 4 Mean nondense breast area for quintiles of sex steroids and sex hormone binding globulin (n = 775)

From: No relationship between circulating levels of sex steroids and mammographic breast density: the Prospect-EPIC cohort

 

Quintile 1

Quintile 2

Quintile 3

Quintile 4

Quintile 5

P value for trend

Oestronea

      

   Crude

85.5 (79.7–91.4)

93.8 (87.5–100.3)

97.5 (91.5–103.6)

95.2 (89.6–101.0)

101.4 (95.5–107.6)

<0.001

   + BMI

90.9 (86.1–95.9)

98.6 (93.4–104.0)

96.1 (91.3–101.0)

93.7 (89.1–98.3)

94.9 (90.1–99.7)

0.74

Oestradiolb

      

   Crude

87.0 (81.3–92.8)

91.6 (85.8–97.6)

94.7 (88.7–100.8)

95.6 (89.6–101.8)

104.9 (98.9–111.2)

<0.0001

   + BMI

95.5 (90.6–100.6)

97.0 (92.1–101.9)

95.5 (90.6–100.4)

91.9 (87.1–96.8)

93.8 (89.0–98.7)

0.36

Free oestradiolc

      

   Crude

85.1 (79.6–90.8)

90.3 (84.6–96.2)

96.2 (90.3–102.2)

94.4 (88.6–100.4)

108.7 (102.4–115.1)

<0.0001

   + BMI

95.1 (90.2–100.2)

95.6 (90.7–100.5)

96.8 (92.0–101.8)

90.8 (86.1–95.7)

95.3 (90.3–100.4)

0.69

Dehydroepiandrosterone sulfated

      

   Crude

96.0 (90.1–102.2)

95.6 (89.7–101.8)

101.0 (94.9–107.3)

91.3 (85.5–97.4)

90.1 (84.3–96.0)

0.06

   + BMI

97.2 (92.3–102.1)

94.7 (89.9–99.6)

99.3 (94.4–104.3)

91.1 (86.4–95.9)

91.6 (86.9–96.4)

0.05

Androstenedionee

      

   Crude

97.9 (91.8–104.2)

93.8 (87.9–99.9)

92.8 (86.8–99.0)

92.7 (86.9–98.6)

96.8 (90.8–103.0)

0.99

   + BMI

101.9 (96.9–107.0)

95.0 (90.2–99.9)

89.8 (85.1–94.7)

93.2 (88.6–97.9)

94.0 (89.3–98.9)

0.10

Testosteronef

      

   Crude

90.8 (84.8–96.9)

90.7 (85.0–96.6)

93.4 (87.5–99.6)

95.8 (89.9–101.8)

103.3 (97.1–109.6)

<0.01

   + BMI

98.1 (93.0–103.3)

92.8 (88.1–97.6)

93.5 (88.7–98.4)

93.9 (89.2–98.7)

95.7 (90.8–100.6)

0.82

Free testosteroneg

      

   Crude

83.6 (78.2–89.3)

88.4 (82.8–94.3)

96.2 (90.3–102.2)

100.3 (94.3–106.5)

106.2 (100.0–112.6)

<0.0001

   + BMI

92.9 (88.1–97.9)

93.2 (88.4–98.1)

96.8 (92.0–101.8)

95.7 (90.9–100.7)

95.0 (90.0–100.0)

0.53

Sex hormone binding globulinh

      

   Crude

110.7 (104.4–117.2)

105.5 (99.5–111.7)

88.6 (83.1–94.2)

92.7 (87.1–98.5)

79.2 (74.0–84.5)

<0.0001

   + BMI

97.0 (91.9–102.3)

101.0 (96.0–106.0)

90.9 (86.3–95.6)

96.7 (91.9–101.6)

88.6 (84.0–93.4)

<0.01

   + BMI and WHR

94.3 (89.2–99.4)

98.8 (94.0–103.8)

91.6 (87.1–96.2)

97.4 (92.7–102.3)

91.3 (86.6–96.1)

0.32

  1. Data presented as the mean (95% confidence interval). BMI, body mass index; WHR, waist–hip ratio. aQuintile cutoff points: 7.45, 12, 15, 20 and 29 pg/ml. bQuintile cutoff points: 4.45, 6.4, 8.2, 10.0 and 14 pg/ml. cQuintile cutoff points: 0.12, 0.18, 0.24, 0.31 and 0.45 pg/ml. dQuintile cutoff points: 188, 333, 479, 666 and 1,041 ng/ml. eQuintile cutoff points: 0.19, 0.36, 0.50, 0.67 and 1.10 ng/m. fQuintile cutoff points: 0.13, 0.20, 0.26, 0.33 and 0.47 ng/m. gQuintile cutoff points: 2.29, 3.98, 5.48, 7.50 and 11.36 pg/ml. hQuintile cutoff points: 6.2, 15, 21, 28 and 43 nmol/l.
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Breast Cancer Research

ISSN: 1465-542X

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