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Table 4 Mean nondense breast area for quintiles of sex steroids and sex hormone binding globulin (n = 775)

From: No relationship between circulating levels of sex steroids and mammographic breast density: the Prospect-EPIC cohort

  Quintile 1 Quintile 2 Quintile 3 Quintile 4 Quintile 5 P value for trend
Oestronea       
   Crude 85.5 (79.7–91.4) 93.8 (87.5–100.3) 97.5 (91.5–103.6) 95.2 (89.6–101.0) 101.4 (95.5–107.6) <0.001
   + BMI 90.9 (86.1–95.9) 98.6 (93.4–104.0) 96.1 (91.3–101.0) 93.7 (89.1–98.3) 94.9 (90.1–99.7) 0.74
Oestradiolb       
   Crude 87.0 (81.3–92.8) 91.6 (85.8–97.6) 94.7 (88.7–100.8) 95.6 (89.6–101.8) 104.9 (98.9–111.2) <0.0001
   + BMI 95.5 (90.6–100.6) 97.0 (92.1–101.9) 95.5 (90.6–100.4) 91.9 (87.1–96.8) 93.8 (89.0–98.7) 0.36
Free oestradiolc       
   Crude 85.1 (79.6–90.8) 90.3 (84.6–96.2) 96.2 (90.3–102.2) 94.4 (88.6–100.4) 108.7 (102.4–115.1) <0.0001
   + BMI 95.1 (90.2–100.2) 95.6 (90.7–100.5) 96.8 (92.0–101.8) 90.8 (86.1–95.7) 95.3 (90.3–100.4) 0.69
Dehydroepiandrosterone sulfated       
   Crude 96.0 (90.1–102.2) 95.6 (89.7–101.8) 101.0 (94.9–107.3) 91.3 (85.5–97.4) 90.1 (84.3–96.0) 0.06
   + BMI 97.2 (92.3–102.1) 94.7 (89.9–99.6) 99.3 (94.4–104.3) 91.1 (86.4–95.9) 91.6 (86.9–96.4) 0.05
Androstenedionee       
   Crude 97.9 (91.8–104.2) 93.8 (87.9–99.9) 92.8 (86.8–99.0) 92.7 (86.9–98.6) 96.8 (90.8–103.0) 0.99
   + BMI 101.9 (96.9–107.0) 95.0 (90.2–99.9) 89.8 (85.1–94.7) 93.2 (88.6–97.9) 94.0 (89.3–98.9) 0.10
Testosteronef       
   Crude 90.8 (84.8–96.9) 90.7 (85.0–96.6) 93.4 (87.5–99.6) 95.8 (89.9–101.8) 103.3 (97.1–109.6) <0.01
   + BMI 98.1 (93.0–103.3) 92.8 (88.1–97.6) 93.5 (88.7–98.4) 93.9 (89.2–98.7) 95.7 (90.8–100.6) 0.82
Free testosteroneg       
   Crude 83.6 (78.2–89.3) 88.4 (82.8–94.3) 96.2 (90.3–102.2) 100.3 (94.3–106.5) 106.2 (100.0–112.6) <0.0001
   + BMI 92.9 (88.1–97.9) 93.2 (88.4–98.1) 96.8 (92.0–101.8) 95.7 (90.9–100.7) 95.0 (90.0–100.0) 0.53
Sex hormone binding globulinh       
   Crude 110.7 (104.4–117.2) 105.5 (99.5–111.7) 88.6 (83.1–94.2) 92.7 (87.1–98.5) 79.2 (74.0–84.5) <0.0001
   + BMI 97.0 (91.9–102.3) 101.0 (96.0–106.0) 90.9 (86.3–95.6) 96.7 (91.9–101.6) 88.6 (84.0–93.4) <0.01
   + BMI and WHR 94.3 (89.2–99.4) 98.8 (94.0–103.8) 91.6 (87.1–96.2) 97.4 (92.7–102.3) 91.3 (86.6–96.1) 0.32
  1. Data presented as the mean (95% confidence interval). BMI, body mass index; WHR, waist–hip ratio. aQuintile cutoff points: 7.45, 12, 15, 20 and 29 pg/ml. bQuintile cutoff points: 4.45, 6.4, 8.2, 10.0 and 14 pg/ml. cQuintile cutoff points: 0.12, 0.18, 0.24, 0.31 and 0.45 pg/ml. dQuintile cutoff points: 188, 333, 479, 666 and 1,041 ng/ml. eQuintile cutoff points: 0.19, 0.36, 0.50, 0.67 and 1.10 ng/m. fQuintile cutoff points: 0.13, 0.20, 0.26, 0.33 and 0.47 ng/m. gQuintile cutoff points: 2.29, 3.98, 5.48, 7.50 and 11.36 pg/ml. hQuintile cutoff points: 6.2, 15, 21, 28 and 43 nmol/l.