No relationship between circulating levels of sex steroids and mammographic breast density: the Prospect-EPIC cohort

Table 3 Mean dense breast area for quintiles of sex steroids and sex hormone binding globulin (n = 775)

	Quintile 1	Quintile 2	Quintile 3	Quintile 4	Quintile 5	P value for trend
Oestrone^a	27.4 (25.3–29.5)	27.3 (25.1–29.6)	27.0 (25.0–29.1)	26.5 (24.6–28.5)	25.2 (23.3–27.2)	0.09
Oestradiol^b	27.9 (25.8–30.0)	27.7 (25.7–29.8)	24.3 (22.4–26.3)	27.2 (25.2–29.4)	26.1 (24.2–28.1)	0.27
Free oestradiol^c	27.8 (25.7–29.9)	27.3 (25.2–29.4)	26.0 (24.0–28.0)	26.3 (24.3–28.3)	25.9 (23.9–28.0)	0.20
Dehydroepiandrosterone sulfate^d	27.8 (25.7–29.9)	26.0 (24.0–28.1)	26.5 (24.5–28.6)	26.2 (24.2–28.3)	26.7 (24.7–28.8)	0.68
Androstenedione^e	26.8 (24.8–28.9)	27.1 (25.1–29.3)	25.5 (23.5–27.6)	28.2 (26.2–30.3)	25.5 (23.5–27.5)	0.44
Testosterone^f	27.1 (25.0–29.2)	27.5 (25.5–29.6)	25.9 (23.9–28.0)	26.3 (24.3–28.3)	26.4 (24.4–28.5)	0.53
Free testosterone^g	28.7 (26.6–30.8)	25.6 (23.7–27.7)	25.3 (23.4–27.4)	27.5 (25.4–29.6)	26.1 (24.1–28.1)	0.36
Sex hormone binding globulin^h	26.3 (24.2–28.4)	26.2 (24.2–28.2)	25.5 (23.6–27.5)	27.7 (25.6–29.8)	27.5 (25.5–29.7)	0.22

Data presented as the mean (95% confidence interval). ^aQuintile cutoff points: 7.45, 12, 15, 20 and 29 pg/ml. ^bQuintile cutoff points: 4.45, 6.4, 8.2, 10.0 and 14 pg/ml. ^cQuintile cutoff points: 0.12, 0.18, 0.24, 0.31 and 0.45 pg/ml. ^dQuintile cutoff points: 188, 333, 479, 666 and 1,041 ng/ml. ^eQuintile cutoff points: 0.19, 0.36, 0.50, 0.67 and 1.10 ng/m. ^fQuintile cutoff points: 0.13, 0.20, 0.26, 0.33 and 0.47 ng/m. ^gQuintile cutoff points: 2.29, 3.98, 5.48, 7.50 and 11.36 pg/ml. ^hQuintile cutoff points: 6.2, 15, 21, 28 and 43 nmol/l.

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