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Table 2 Mean percentage breast density for quintiles of sex steroids and sex hormone binding globulin (n = 775)

From: No relationship between circulating levels of sex steroids and mammographic breast density: the Prospect-EPIC cohort

 

Quintile 1

Quintile 2

Quintile 3

Quintile 4

Quintile 5

P value for trend

Oestronea

   Crude

24.7 (22.8–26.7)

22.6 (20.7–24.6)

22.0 (20.3–23.9)

22.3 (20.6–24.0)

20.1 (18.5–21.8)

<0.01

   + BMI

23.6 (21.9–25.5)

21.8 (20.0–23.6)

22.3 (20.6–24.0)

22.6 (21.0–24.2)

21.2 (19.6–22.9)

0.12

Oestradiolb

   Crude

24.7 (22.8–26.6)

23.4 (21.6–25.3)

20.8 (19.1–22.6)

22.5 (20.7–24.4)

20.2 (18.5–21.9)

<0.001

   + BMI

23.1 (21.4–24.9)

22.5 (20.8–24.3)

20.7 (19.1–22.4)

23.1 (21.4–25.0)

22.0 (20.3–23.7)

0.58

Free oestradiolc

   Crude

24.9 (23.1–26.9)

23.5 (21.7–25.4)

21.6 (19.8–23.4)

22.0 (20.3–23.8)

19.5 (17.9–21.2)

<0.0001

   + BMI

23.1 (21.4–24.9)

22.5 (20.9–24.3)

21.5 (19.8–23.2)

22.6 (20.9–24.4)

21.6 (19.9–23.4)

0.34

Dehydroepiandrosterone sulfated

   Crude

22.7 (20.9–24.6)

21.9 (20.1–23.8)

20.9 (19.1–22.7)

22.8 (21.0–24.6)

23.1 (21.3–25.0)

0.44

   + BMI

22.5 (20.8–24.3)

22.1 (20.4–23.8)

21.2 (19.5–22.9)

22.8 (21.1–24.6)

22.8 (21.1–24.6)

0.54

Androstenedionee

   Crude

21.8 (20.0–23.7)

22.9 (21.0–24.7)

22.0 (20.2–23.8)

23.6 (21.8–25.5)

21.1 (19.4–22.9)

0.52

   + BMI

21.1 (19.5–22.9)

22.7 (21.0–24.4)

22.5 (20.8–24.3)

23.5 (21.8–25.3)

21.6 (19.9–23.3)

0.88

Testosteronef

   Crude

23.2 (21.4–25.2)

23.8 (22.0–25.7)

22.2 (20.4–24.1)

21.7 (20.0–23.5)

20.5 (18.8–22.2)

0.01

   + BMI

21.9 (20.2–23.7)

23.4 (21.7–25.2)

22.2 (20.5–24.0)

22.1 (20.4–23.8)

21.7 (20.1–23.5)

0.48

Free testosteroneg

   Crude

26.0 (24.1–28.0)

22.9 (21.1–24.8)

21.1 (19.4–22.9)

21.7 (20.0–23.5)

19.8 (18.1–21.5)

<0.0001

   + BMI

24.2 (22.5–26.1)

22.1 (20.4–23.8)

21.0 (19.4–22.7)

22.5 (20.8–24.2)

21.6 (19.9–23.3)

0.13

Sex hormone binding globulinh

   Crude

19.3 (17.6–21.0)

20.1 (18.5–21.9)

22.8 (21.0–24.6)

23.0 (21.2–24.9)

26.2 (24.4–28.2)

<0.0001

   + BMI

21.4 (19.7–23.2)

20.8 (19.2–22.5)

22.4 (20.7–24.1)

22.4 (20.7–24.1)

24.4 (22.6–26.3)

<0.01

   + BMI and WHR

21.9 (20.2–23.8)

21.4 (19.7–23.1)

22.2 (20.6–23.9)

22.2 (20.5–23.9)

23.7 (21.9–25.5)

0.11

  1. Data presented as the mean (95% confidence interval). BMI, body mass index; WHR, waist–hip ratio. aQuintile cutoff points: 7.45, 12, 15, 20 and 29 pg/ml. bQuintile cutoff points: 4.45, 6.4, 8.2, 10.0 and 14 pg/ml. cQuintile cutoff points: 0.12, 0.18, 0.24, 0.31 and 0.45 pg/ml. dQuintile cutoff points: 188, 333, 479, 666 and 1,041 ng/ml. eQuintile cutoff points: 0.19, 0.36, 0.50, 0.67 and 1.10 ng/m. fQuintile cutoff points: 0.13, 0.20, 0.26, 0.33 and 0.47 ng/m. gQuintile cutoff points: 2.29, 3.98, 5.48, 7.50 and 11.36 pg/ml. hQuintile cutoff points: 6.2, 15, 21, 28 and 43 nmol/l.
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Breast Cancer Research

ISSN: 1465-542X

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