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Table 2 Mean percentage breast density for quintiles of sex steroids and sex hormone binding globulin (n = 775)

From: No relationship between circulating levels of sex steroids and mammographic breast density: the Prospect-EPIC cohort

  Quintile 1 Quintile 2 Quintile 3 Quintile 4 Quintile 5 P value for trend
Oestronea
   Crude 24.7 (22.8–26.7) 22.6 (20.7–24.6) 22.0 (20.3–23.9) 22.3 (20.6–24.0) 20.1 (18.5–21.8) <0.01
   + BMI 23.6 (21.9–25.5) 21.8 (20.0–23.6) 22.3 (20.6–24.0) 22.6 (21.0–24.2) 21.2 (19.6–22.9) 0.12
Oestradiolb
   Crude 24.7 (22.8–26.6) 23.4 (21.6–25.3) 20.8 (19.1–22.6) 22.5 (20.7–24.4) 20.2 (18.5–21.9) <0.001
   + BMI 23.1 (21.4–24.9) 22.5 (20.8–24.3) 20.7 (19.1–22.4) 23.1 (21.4–25.0) 22.0 (20.3–23.7) 0.58
Free oestradiolc
   Crude 24.9 (23.1–26.9) 23.5 (21.7–25.4) 21.6 (19.8–23.4) 22.0 (20.3–23.8) 19.5 (17.9–21.2) <0.0001
   + BMI 23.1 (21.4–24.9) 22.5 (20.9–24.3) 21.5 (19.8–23.2) 22.6 (20.9–24.4) 21.6 (19.9–23.4) 0.34
Dehydroepiandrosterone sulfated
   Crude 22.7 (20.9–24.6) 21.9 (20.1–23.8) 20.9 (19.1–22.7) 22.8 (21.0–24.6) 23.1 (21.3–25.0) 0.44
   + BMI 22.5 (20.8–24.3) 22.1 (20.4–23.8) 21.2 (19.5–22.9) 22.8 (21.1–24.6) 22.8 (21.1–24.6) 0.54
Androstenedionee
   Crude 21.8 (20.0–23.7) 22.9 (21.0–24.7) 22.0 (20.2–23.8) 23.6 (21.8–25.5) 21.1 (19.4–22.9) 0.52
   + BMI 21.1 (19.5–22.9) 22.7 (21.0–24.4) 22.5 (20.8–24.3) 23.5 (21.8–25.3) 21.6 (19.9–23.3) 0.88
Testosteronef
   Crude 23.2 (21.4–25.2) 23.8 (22.0–25.7) 22.2 (20.4–24.1) 21.7 (20.0–23.5) 20.5 (18.8–22.2) 0.01
   + BMI 21.9 (20.2–23.7) 23.4 (21.7–25.2) 22.2 (20.5–24.0) 22.1 (20.4–23.8) 21.7 (20.1–23.5) 0.48
Free testosteroneg
   Crude 26.0 (24.1–28.0) 22.9 (21.1–24.8) 21.1 (19.4–22.9) 21.7 (20.0–23.5) 19.8 (18.1–21.5) <0.0001
   + BMI 24.2 (22.5–26.1) 22.1 (20.4–23.8) 21.0 (19.4–22.7) 22.5 (20.8–24.2) 21.6 (19.9–23.3) 0.13
Sex hormone binding globulinh
   Crude 19.3 (17.6–21.0) 20.1 (18.5–21.9) 22.8 (21.0–24.6) 23.0 (21.2–24.9) 26.2 (24.4–28.2) <0.0001
   + BMI 21.4 (19.7–23.2) 20.8 (19.2–22.5) 22.4 (20.7–24.1) 22.4 (20.7–24.1) 24.4 (22.6–26.3) <0.01
   + BMI and WHR 21.9 (20.2–23.8) 21.4 (19.7–23.1) 22.2 (20.6–23.9) 22.2 (20.5–23.9) 23.7 (21.9–25.5) 0.11
  1. Data presented as the mean (95% confidence interval). BMI, body mass index; WHR, waist–hip ratio. aQuintile cutoff points: 7.45, 12, 15, 20 and 29 pg/ml. bQuintile cutoff points: 4.45, 6.4, 8.2, 10.0 and 14 pg/ml. cQuintile cutoff points: 0.12, 0.18, 0.24, 0.31 and 0.45 pg/ml. dQuintile cutoff points: 188, 333, 479, 666 and 1,041 ng/ml. eQuintile cutoff points: 0.19, 0.36, 0.50, 0.67 and 1.10 ng/m. fQuintile cutoff points: 0.13, 0.20, 0.26, 0.33 and 0.47 ng/m. gQuintile cutoff points: 2.29, 3.98, 5.48, 7.50 and 11.36 pg/ml. hQuintile cutoff points: 6.2, 15, 21, 28 and 43 nmol/l.