Baseline-adjusted AUC0–24 week for serum concentrations of PINP in the evaluable population. The increase in baseline-adjusted AUC0–24 week for exemestane was 187% (95% CI, 95–295%). The AUC0–24 week for exemestane was significantly greater than anastrozole (P = 0.004), letrozole (P < 0.001), or placebo (P = 0.033). Changes in baseline-adjusted AUC0–24 week were not statistically significant for other active treatments or placebo. The overall differences between the four groups were statistically significant (P = 0.004 using the Kruskall–Wallis test). AUC, area under the curve; PINP, procollagen type I N-terminal propeptide.