Breast Cancer Research

Table 2 Sensitivity and specificity at the 10% cutoff point for prediction of identifying a BRCA1/2 mutation in non-Ashkenazi Jewish families for four models/scoring systems based on four validation studies

From: Breast cancer risk-assessment models

	Barcenas and colleagues [53]		Amir and colleagues [27]		James and colleagues [54]
Study	Sensitivity	Specificity	Sensitivity	Specificity	Sensitivity	Specificity
n	472 (96 mutation-positive)		258 (23 mutation-positive)		209 (51 mutation-positive)
Both mutations
BOADICEA	73	67
BRCAPRO	73	67	61	44	81	66
Myriad 2	68	63	87	33	97	23
Manchester scoring	93	41	87	66	81	58
BRCA1 mutation
BOADICEA	61	84
BRCAPRO	75	71	67	56	88	66
Myriad 1	72	60	100	0	100	23
Manchester scoring	83	55	67	17	91	60
BRCA2 mutation
BOADICEA	48	78
BRCAPRO	40	85	6	83	74	66
Myriad 1	40	89	79	11	94	23
Manchester scoring	84	58	82	75	71	60

BOADICEA = Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm.

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ISSN: 1465-542X

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