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Figure 7 | Breast Cancer Research

Figure 7

From: The zinc finger domain of Wilms' tumor 1 suppressor gene (WT1) behaves as a dominant negative, leading to abrogation of WT1 oncogenic potential in breast cancer cells

Figure 7

Accelerated apoptosis in the zinc finger domain lacking lysine–threonine–serine-transfected MCF-7 cells. Dot plots of a representative experiment of flow cytometric analysis for staining of Annexin V–PE (horizontal axis) and 7-amino-actinomycin D (7-AAD) (vertical axis) in nontransfected MCF-7 cells (CON) and transfected MCF-7 cells (Vec, zinc finger domain lacking the lysine–threonine–serine insert (ZF - KTS) or full-length Wilms' tumor 1 suppressor gene (WT1)). Percentages of cell populations in the different quadrants are indicated. Days after G418 selection are shown.

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