Expression of truncated Int6/eIF3e in mammary alveolar epithelium leads to persistent hyperplasia and tumorigenesis

Table 1 Mammary tumor incidence in WapInt6sh female transgenic mice compared with wild-type female FVB/N mice at 24 months of age.

Strain and genotype	No. of mice with tumors	Total mice (N)	Tumor incidence (%)	Fisher's exact test p value	Reference
FVB/N wild-type^a	0	71	0	<0.00001^b	[17]
FVB/N wild-type, multiparous^c	0	22	0	0.0006^d	[16]
FVB/N WapInt6sh virgins	1^e	26^f	3.8%	0.0016^g	This work
FVB/N wild-type, multiparous^h	0	8	0	0.035ⁱ	This work
FVB/N WapInt6sh, multiparous	10^j	24^k	41.7%	NA	This work

^aReported by the National Institute for Environmental Health Sciences. For this comparison, only histological malignant lesions were scored as tumors; adenomas and other benign lesions were not included.
^bp < 0.00001 from the Fisher's exact test of previously published tumor incidence in FVB/N wild-type mice vs WapInt6sh multiparous females (row 1 vs row 5).
^cIncludes all frank tumors classified histopathologically as adenomas or adenocarcinomas.
^dp = 0.0006 from the Fisher's exact test of previously published tumor incidence in FVB/N wild-type multiparous mice vs WapInt6sh multiparous females (row 2 vs row 5).
^eHistologically, a papillary adenocarcinoma
^fTotal mice included 21 heterozygous and 5 homozygous WapInt6sh transgenic mice from J1 founder line that survived 24 months or longer.
^gp = 0.0016 from the Fisher's exact test of WapInt6sh virgins vs WapInt6sh multiparous females (row 3 vs row 5).
^hIncludes multiparous FVB/N wild-type littermates resulting from WapInt6sh heterozygous crosses. Each mouse is identified in Additional file 3.
ⁱp = 0.035 from the Fisher's exact test of wild-type multiparous vs WapInt6sh multiparous females (row 4 vs row 5).
^jOf the 11 tumors arising in 10 multiparous transgenic females, there were 4 undifferentiated tumors, 5 papillary adenocarcinomas and 2 glandular adenocarcinomas.
^kTotal mice included both heterozygous or homozygous WapInt6sh transgenic mice from J1 founder line that lived to tumor age (>12 months) and produced >1 litter.

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