Figure 8

Response to anti-oestrogen therapy. (a) Tumour cells were recovered from a mouse, then grown in the presence of oestradiol (E) or fulvestrant (F). (b,c) Mammary glands of mice that received an oestrogen pellet before injection of the tumour cells, followed by either no additional treatment (b) or weekly subcutaneous injections of fulvestrant to block oestrogen signalling (c). Upper panels, normal light; lower panels, cyan fluorescent protein (CFP) fluorescence. Only the human mammary epithelial cells were infected with the CFP-expressing virus in this experiment.