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- Open Access
Identification of individuals with hereditary predisposition to breast cancer and other breast cancer-associated forms of malignant neoplasms: data of the Belarusian Cancer Registry
Breast Cancer Research volume 9, Article number: SP20 (2007)
Nowadays, all developed countries spend enormous resources on breast cancer (BC) treatment. However, no significant reduction in the population's BC rates due to the improvement of treatment methods can be expected in the near future.
To use the data of the Belarusian Cancer Registry (BCR) for active identification of individuals with hereditary predisposition to BC and other BC-associated forms of malignant neoplasms.
Materials and methods
To make the analysis, 4,442 patients with second primaries (SP), one of which was BC, were selected, as well as BC patients with disease origination before age 40. There were 7,137 such patients.
BC was most commonly associated with skin cancer (24.9%), endometrial cancer (11.8%), ovarian cancer (9%), gastric cancer (7.8%), cervical cancer (5.9%), rectum cancer (5.2%), thyroid cancer (5%), colon cancer (4.8%), renal cancer (3.6%), lung cancer (3.4%), skin melanoma (2.3%) and other cancers (16.3%). The fate of each patient was retraced.
(1) BCR data enable one to identify individuals potentially predisposed to hereditary BC and other BC-associated forms of malignancies, according to two features. (2) Using the risk factors for development of hereditary BC and other BC-associated forms of malignant neoplasms makes it possible to draw the relatives of the identified individuals into genetic consulting. (3) The rates of BC association with other forms of malignancies in SP patients were evaluated in the Belarusian population. (4) The use of BCR data and active involvement of relatives of persons with a cancer burden in oncogenetic consulting offer opportunities for early diagnosis and prevention of hereditary BC and other BC-associated forms of malignant neoplasms.