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Table 5 Univariate and multivariate Cox analyses in The Netherlands Cancer Institute data set (n = 295)

From: Low E2F1 transcript levels are a strong determinant of favorable breast cancer outcome

Factor

Univariate metastasis-free survival

Multivariate metastasis-free survivala

 

Hazard ratio (95% confidence interval)

P value

With 70-gene signature

Without 70-gene signature

   

Hazard ratio (95% confidence interval)

P value

Hazard ratio (95% confidence interval)

P value

E2F1 (>p30 versus ≤ p30)

5.09 (2.65–9.78)

<0.001

3.76 (1.90–7.45)

<0.001

2.47 (1.20–5.10)

0.014

Grade (3 versus 1 + 2)

2.38 (1.60–3.52)

<0.001

1.28 (0.82–2.00)

0.277

1.02 (0.65–1.60)

0.931

Estrogen receptor status (positive versus negative)

0.54 (0.36–0.83)

0.005

0.99 (0.61–1.59)

0.956

1.11 (0.70–1.78)

0.658

ERBB2 status (positive versus negative)

1.61 (1.01–2.57)

0.045

1.35 (0.82–2.21)

0.234

1.28 (0.78–2.09)

0.330

pN (>3 nodes versus ≤ 3 nodes)

2.20 (1.37–3.53)

0.001

2.35(1.32–4.21)

0.004

2.69 (1.47–4.91)

0.001

Size (>2 cm versus ≤ 2 cm)

2.08 (1.39–3.10)

<0.001

1.70 (1.12–2.58)

0.013

1.73 (1.14–2.62)

0.010

Age (≤ 40 years versus >40 years)

0.50 (0.33–0.75)

0.001

0.59 (0.38–0.89)

0.013

0.67 (0.43–1.02)

0.063

Chemotherapy

0.79 (0.52–1.19)

0.254

0.61 (0.38–1.00)

0.051

0.55 (0.33–0.91)

0.020

Hormone therapy

0.58 (0.28–1.19)

0.139

0.60 (0.28–1.27)

0.181

0.58 (0.27–1.23)

0.157

70-gene signature (poor versus good prognosis)

4.55 (2.67–7.77)

<0.001

Not included

Not included

2.78 (1.49–5.21)

0.001

  1. aMultivariate metastasis-free survival calculated once with and once without the 70-gene signature.