Table 4 Univariate and multivariate Cox analyses in the Stiftung Tumorbank Basel data set (n = 317)

E2F1 (>p30 versus ≤ p30)

4.27 (1.83–9.96)

0.001

2.95 (1.10–7.93)

0.032

Grade (3 versus 1 + 2)

2.03 (1.17–3.51)

0.011

1.56 (0.77–3.14)

0.213

Estrogen receptor status (positive versus negative)

0.64 (0.37–1.12)

0.120

1.21 (0.56–2.61)

0.625

ERBB2 status (positive versus negative)

1.69 (0.98–2.92)

0.058

1.41 (0.70–2.81)

0.335

pN (>3 nodes versus ≤ 3 nodes)

3.14 (1.76–5.61)

<0.001

2.36 (1.14–4.88)

0.021

Size (>2 cm versus ≤ 2 cm)

1.95 (1.05–3.62)

0.036

1.19 (0.58–2.43)

0.641

Age (≤ 40 years versus >40 years)

0.30 (0.15–0.59)

0.001

0.59 (0.24–1.43)

0.246

Chemotherapy

2.65 (1.54–4.55)

<0.001

1.27 (0.45–3.59)

0.654

Hormone therapy

0.50 (0.28–0.88)

0.017

0.76 (0.27–2.17)

0.605

70-gene signature (poor versus good prognosis)

Not available

Not available

Not available

Not available