Table 4 Spearman correlation coefficients (P values) between cord blood sex hormones, growth factors, and associated binding proteins and hematopoietic stem/progenitor cell populations among different racial/ethnic groups
Stem/progenitor cell measurement | Estradiol | Estriol | Testosterone | Sex hormone-binding globulin | Progesterone | Prolactin | Insulin-like growth factor-1 | Insulin-like growth factor binding protein-3 |
|---|---|---|---|---|---|---|---|---|
Both parents Caucasian (n = 147) | ||||||||
CD34+/103 MNC | 0.12 (0.16) | 0.16 (0.06) | -0.04 (0.59) | -0.18 (0.03) | -0.01 (0.87) | -0.05 (0.52) | 0.24 (0.003) | 0.12 (0.15) |
CD34+CD38-/103 MNC | 0.13 (0.12) | 0.25 (0.002) | 0.05 (0.53) | -0.16 (0.05) | -0.02 (0.80) | -0.02 (0.80) | 0.23 (0.004) | 0.05 (0.58) |
CD34+c-kit +/103 MNC | 0.21 (0.03) | 0.30 (0.001) | 0.05 (0.61) | -0.17 (0.07) | -0.001 (0.99) | 0.10 (0.29) | 0.26 (0.005) | 0.09 (0.32) |
GM-CFU/103 MNC | 0.11 (0.32) | 0.24 (0.03) | 0.13 (0.24) | -0.16 (0.16) | -0.02 (0.88) | 0.13 (0.25) | 0.24 (0.03) | 0.07 (0.56) |
Both parents African-American (n = 20) | ||||||||
CD34+/103 MNC | -0.25 (0.28) | -0.27 (0.24) | -0.22 (0.34) | -0.33 (0.16) | -0.14 (0.57) | -0.23 (0.32) | 0.09 (0.71) | 0.19 (0.41) |
CD34+CD38-/103 MNC | -0.25 (0.28) | 0.008 (0.97) | -0.08 (0.75) | -0.32 (0.18) | -0.10 (0.67) | -0.02 (0.93) | -0.003 (0.99) | 0.86 (0.72) |
CD34+c-kit +/103 MNC | -0.40 (0.09) | -0.38 (0.11) | -0.31 (0.19) | -0.42 (0.07) | -0.23 (0.34) | -0.34 (0.15) | 0.12 (0.63) | 0.30 (0.20) |
GM-CFU/103 MNC | -0.39 (0.15) | -0.40 (0.14) | -0.25 (0.36) | -0.52 (0.04) | -0.42 (0.12) | -0.13 (0.63) | -0.02 (0.94) | 0.35 (0.20) |
Both parents Asian-American (n = 39) | ||||||||
CD34+/103 MNC | 0.14 (0.38) | 0.09 (0.58) | 0.22 (0.19) | 0.08 (0.65) | 0.15 (0.37) | 0.19 (0.25) | 0.15 (0.36) | 0.06 (0.73) |
CD34+CD38-/103 MNC | 0.14 (0.93) | 0.07 (0.66) | 0.17 (0.29) | 0.03 (0.86) | 0.08 (0.62) | 0.14 (0.40) | 0.15 (0.35) | 0.004 (0.98) |
CD34+c-kit +/103 MNC | 0.13 (0.42) | 0.10 (0.53) | 0.19 (0.24) | 0.08 (0.64) | 0.15 (0.35) | 0.19 (0.26) | 0.16 (0.35) | 0.05 (0.75) |
GM-CFU/103 MNC | 0.26 (0.25) | 0.22 (0.33) | 0.24 (0.30) | 0.26 (0.26) | 0.24 (0.29) | 0.09 (0.71) | 0.31 (0.17) | 0.06 (0.78) |
Both parents Hispanic-American (n = 15) | ||||||||
CD34+/103 MNC | 0.45 (0.10) | -0.16 (0.58) | -0.38 (0.17) | -0.04 (0.90) | -0.06 (0.83) | 0.14 (0.63) | 0.51 (0.05) | 0.01 (0.97) |
CD34+CD38-/103 MNC | 0.60 (0.02) | 0.24 (0.40) | 0.01 (0.96) | -0.21 (0.45) | 0.09 (0.76) | 0.14 (0.61) | 0.38 (0.16) | -0.11 (0.70) |
CD34+c-kit +/103 MNC | 0.38 (0.19) | -0.05 (0.86) | -0.35 (0.22) | -0.19 (0.51) | 0.16 (0.57) | 0.23 (0.44) | 0.62 (0.02) | 0.07 (0.82) |
GM-CFU/103 MNC | -0.01 (0.98) | -0.47 (0.24) | -0.49 (0.22) | -0.46 (0.26) | 0.22 (0.61) | -0.25 (0.55) | 0.25 (0.55) | -0.20 (0.63) |
Parents of differing ethnicity/race (mixed) (n = 31) | ||||||||
CD34+/103 MNC | -0.06 (0.74) | -0.14 (0.46) | -0.03 (0.85) | -0.07 (0.71) | 0.009 (0.96) | 0.21 (0.25) | 0.03 (0.87) | 0.05 (0.80) |
CD34+CD38-/103 MNC | -0.19 (0.32) | -0.18 (0.32) | -0.08 (0.68) | -0.03 (0.86) | -0.05 (0.79) | 0.33 (0.07) | 0.08 (0.65) | 0.25 (0.18) |
CD34+c-kit +/103 MNC | 0.03 (0.87) | 0.005 (0.98) | -0.002 (0.99) | -0.08 (0.68) | 0.004 (0.98) | 0.19 (0.31) | -0.04 (0.83) | -0.02 (0.93) |
GM-CFU/103 MNC | 0.19 (0.38) | 0.23 (0.27) | 0.24 (0.27) | -0.20 (0.34) | 0.20 (0.34) | 0.01 (0.95) | 0.11 (0.62) | 0.08 (0.72) |