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Table 3 Multiple linear regression analysisa for the association between measurements of hematopoietic stem cell populations and umbilical cord blood plasma levels of hormones and associated binding proteins

From: Correlation of umbilical cord blood hormones and growth factors with stem cell potential: implications for the prenatal origin of breast cancer hypothesis

Hormone/binding protein CD34+ cells/103 mononuclear cells CD34+ CD38-/103 mononuclear cells CD34+c-kit +/103 mononuclear cellsb Granulocyte–macrophage colony-forming units/103 mononuclear cellsc
  % changed (95% confidence interval) P value % change (95% confidence interval) P value % change (95% confidence interval) P value % change (95% confidence interval) P value
Estradiol 3.8 (-4.6, 13.0) 0.39 3.0 (-6.1, 13.0) 0.52 6.6 (-4.4, 18.9) 0.25 2.6 (-8.9, 15.6) 0.67
Estriol 7.5 (-2.6, 18.6) 0.15 11.1 (-0.1, 23.6) 0.05 12.9 (0.8, 26.5) 0.04 10.4 (-3.0, 25.7) 0.13
Testosterone 0.2 (-7.4, 8.5) 0.95 2.1 (-6.3, 11.3) 0.63 2.3 (-6.3, 11.6) 0.62 0.2 (-8.4, 9.5) 0.97
Sex hormone-binding globulin -7.9 (-15.3, 0.1) 0.05 -7.4 (-15.5, 1.5) 0.10 -8.3 (-17.0, 1.2) 0.09 -6.6 (-16.2, 4.1) 0.21
Progesterone -0.2 (-8.3, 8.7) 0.97 -1.9 (-10.6, 7.6) 0.69 -0.9 (-9.9, 9.1) 0.86 0.8 (-10.1, 13.0) 0.90
Prolactin -0.4 (-8.4, 8.4) 0.93 1.3 (-7.6, 11.0) 0.78 5.3 (-4.6, 16.1) 0.30 4.8 (-6.3, 17.2) 0.41
Insulin-like growth factor-1 17.3 (7.2, 28.4) 0.001 16.4 (5.5, 28.5) 0.003 19.2 (7.7, 32.0) 0.001 15.1 (2.6, 29.1) 0.02
Insulin-like growth factor binding protein-3 10.8 (1.3, 21.3) 0.03 8.1 (-2.1, 19.3) 0.12 10.9 (0.02, 23.0) 0.05 9.7 (-2.3, 23.0) 0.12
  1. aFrom multiple regression model, adjusting for mother's age, race of parents (both Caucasian or not), number of live births, gestation duration, gender of baby, and delivery time (day or night). The study site (American Red Cross or Tufts–New England Medical Center) was also adjusted in the analysis of the pooled samples. bDetermined only in the Tufts–New England Medical Center-derived samples (n = 249). cData only from the Tufts–New England Medical Center-derived samples (n = 175). d% change, expected proportional change in dependent variable associated with one standard-deviation increase per independent variable.