An international initiative to identify genetic modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers: the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA)

Table 1 Simulated power (%) to detect a polymorphism with varying minor allele frequency and risk ratio, under a multiplicative model at a significance level 10^-4

Minor allele frequency	Relative hazard	Sample size: 5000	Sample size: 10,000
0.10	1.1	2	7
	1.2	33	80
	1.3	86	100
0.20	1.1	5	26
	1.2	74	100
	1.3	100	100
0.30	1.1	10	44
	1.2	89	100
	1.3	100	100

ISSN: 1465-542X