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Table 1 Simulated power (%) to detect a polymorphism with varying minor allele frequency and risk ratio, under a multiplicative model at a significance level 10-4

From: An international initiative to identify genetic modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers: the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA)

Minor allele frequency Relative hazard Sample size: 5000 Sample size: 10,000
0.10 1.1 2 7
  1.2 33 80
  1.3 86 100
0.20 1.1 5 26
  1.2 74 100
  1.3 100 100
0.30 1.1 10 44
  1.2 89 100
  1.3 100 100
  1. Simulations performed as in [5].