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Table 1 SNP tagging details and data for each gene

From: Common variants in the ATM, BRCA1, BRCA2, CHEK2 and TP53 cancer susceptibility genes are unlikely to increase breast cancer risk

Gene

SNP source

Total SNPs with MAF > 0.05

Total SNPs after exclusion of African subjects

No. of Tag SNPs selected for r2 > 0.8

Usable SNPs

No. of SNPs tagged with rp2 > 0.8 (percent)

No. of SNPs tagged with rp 2 > 0.5 (percent)

No. of SNPs tagged with r2S > 0.8 (percent)

ATM

EGP

75

69

9

9

64 (92)

69 (100)

65 (94)

BRCA1

EGP

123

113

8

5

67 (59)

109 (96)

77 (68)

BRCA2

EGP

113

91

22

16

53 (58)

86 (95)

61 (67)

CHEK2

HAPMAP

30

N/A

10

10

16 (53)

20 (67)

22 (73)

TP53

EGP

46

39

6

5

24 (61)

35 (90)

31 (79)

  1. EGP, NIEHS Environmental Genome Project; MAF, minor allele frequency; SNP, single nucleotide polymorphism.