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Table 5 Frequencies of CBC patients carrying apathogenic DNA-damage repair pathway mutation

From: Identification of women with an increased risk of developing radiation-induced breast cancer: a case only study

Interval (years)

All CBC patients

Previous RT

No RT

Carriers versus non-carriers

 

n

Percentage

n

Percentage

n

Percentage

OR for CBC after RT

95% CI

p

1–5 (n = 66)

15/66

22.7

12/49

24.5

3/16

18.8

1.41

0.34–5.78

 

>5 (n = 181)

36/181

19.9

29/120

24.1

7/62

11.3

2.51

1.03–6.10

0.049

  1. All contralateral breast cancer (CBC) patients, and patients stratified by previous radiation exposure are presented, according to interval between first and second primary breast cancer (less than 5 and more than 5 years). Odds ratio (OR) and 95% confidence interval (CI) are given for mutation carriers versus non-carriers to develop radiation-associated breast cancer. RT, radiation treatment.
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Breast Cancer Research

ISSN: 1465-542X

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