Skip to main content

Table 3 Frequencies of CBC patients carrying pathogenic DNA-damage repair pathway and ATM missense mutations

From: Identification of women with an increased risk of developing radiation-induced breast cancer: a case only study

Parameter All CBC patients (n = 247) Previous RT (n = 169) No RT (n = 78) Carriers versus non-carriers
  n Percentage n Percentage n Percentage OR for CBC after RT 95% CI p
DDRP mutated 51 21 41 24.3 10 12.8 2.18 1.03–4.62 0.043
All patients with only a pathogenic DDRP mutation 37 15 29 17.2 8 10.3 1.8 0.79–4.17  
Patients with both a pathogenic DDRP and an ATM missense mutation 14 5.7 12 7.1 2 2.6 2.90 0.63–13.30  
Patients with only an ATM missense mutation 29 11.7 21 12.4 8 10.3 1.24 0.52–2.94  
  1. Results for all contralateral breast cancer (CBC) patients, and patients stratified by previous radiation exposure, are presented. Odds ratio (OR) and 95% confidence interval (CI) are given for mutation carriers versus non-carriers to develop radiation-associated breast cancer. DDRP, DNA-damage repair pathway; RT, radiation treatment.
\