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Table 1 Tumour and patient characteristics, by DDRP mutation carrier status and previous RT exposure

From: Identification of women with an increased risk of developing radiation-induced breast cancer: a case only study

Characteristic Mutation positive (n = 51) Mutation negative (n = 196)
  Previous RT No previous RT Previous RT No previous RT
Age at first BC, years 40.3 42.4 41.4 42.3
Age at second BC, years 48.1 51.8 51.1 54.2
Chemotherapy, n (percentage) 11 (27) 1 (10) 28 (22) 5 (7)
Tumour size, cm 1.8 2.9 2.2 2.3
Lymph node positive, n (percentage) 12 (29) 1 (10) 41 (32) 4 (6)
RT dosea, Gy     
   Mean (range) 1.49 (0.27–3.73)   1.55 (0.24–5.61)  
   Median 1.32   1.40  
   Third quartile 1.79   1.89  
  1. DDRP, DNA-damage repair pathway; BC, breast cancer; RT, radiation treatment. aRadiation dose to the site of the breast where the tumour had developed.
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