Table 2 Statistics of key gene ontology categories by mechanism of regulation in 728 E2 + ERβ downregulated genes
Gene function | Percentage total | χ2 p value |
|---|---|---|
'Synergistic' | ||
Apoptosis | 0% (0/129) | 0.33018 |
Cell cycle | 0.8% (1/129) | 0.47730 |
Cell proliferation | 0% (0/129) | 0.53595 |
DNA replication | 0.8% (1/129) | 0.67051 |
'Attenuation' | ||
Apoptosis | 0.4% (2/492) | 0.40303 |
Cell cycle | 1.8% (9/492) | 0.11725 |
Cell proliferation | 0.2% (1/492) | 0.70713 |
DNA replication | 1.6% (8/492) | 0.00080 |
'Antagonistic' | ||
Apoptosis | 0.9% (1/107) | 0.80404 |
Cell cycle | 8.4% (6/107) | 0.00077 |
Cell proliferation | 0.9% (1/107) | 0.22828 |
DNA replication | 0.9% (1/107) | 0.53640 |
All genes on array | ||
Apoptosis | 0.7% (138/18,912) | - |
Cell cycle | 1.5% (293/18,912) | - |
Cell proliferation | 0.3% (56/18,912) | - |
DNA replication | 0.5% (96/18,912) | - |