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Table 4 Cox proportional hazards analysis for predictors of disease-free and overall survival: effects of tumour grade, size, lymph node stage, oestrogen receptor (ER) status and FGFR1 status in ER-positive and ER-negative tumours

From: FGFR1 amplification in breast carcinomas: a chromogenic in situhybridisation analysis

Variable ER-positive tumours ER-negative tumours
  Hazard ratio 95% confidence interval P value Hazard ratio 95% confidence interval P value
Disease-free interval       
   Gradea 1.387 1.027–1.874 0.033 1.001 0.637–1.574 0.996
   Tumour size ≥1.5 cmb 1.551 0.926–2.595 0.095 2.348 1.092–5.052 0.029
   Positive lymph node stage 1.407 0.879–2.252 0.155 2.597 1.563–4.315 0.000
   FGFR1 amplification 2.250 1.184–4.274 0.013 1.104 0.440–2.774 0.833
Overall survival       
   Gradea 2.600 1.471–4.594 0.001 1.673 0.731–3.829 0.223
   Tumour size ≥1.5 cmb 2.124 0.792–5.697 0.134 2.594 0.911–7.387 0.074
   Positive lymph node stage 1.973 0.953–4.083 0.067 5.124 2.646–9.924 0.000
   FGFR1 amplification 3.389 1.374–8.358 0.008 1.278 0.450–3.624 0.645
  1. aFitted as a linear term; that is, an increase in risk for change in grade of one unit.
  2. bCompared with tumour size <1.5 cm.