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Table 4 Cox proportional hazards analysis for predictors of disease-free and overall survival: effects of tumour grade, size, lymph node stage, oestrogen receptor (ER) status and FGFR1 status in ER-positive and ER-negative tumours

From: FGFR1 amplification in breast carcinomas: a chromogenic in situhybridisation analysis

Variable

ER-positive tumours

ER-negative tumours

 

Hazard ratio

95% confidence interval

P value

Hazard ratio

95% confidence interval

P value

Disease-free interval

      

   Gradea

1.387

1.027–1.874

0.033

1.001

0.637–1.574

0.996

   Tumour size ≥1.5 cmb

1.551

0.926–2.595

0.095

2.348

1.092–5.052

0.029

   Positive lymph node stage

1.407

0.879–2.252

0.155

2.597

1.563–4.315

0.000

   FGFR1 amplification

2.250

1.184–4.274

0.013

1.104

0.440–2.774

0.833

Overall survival

      

   Gradea

2.600

1.471–4.594

0.001

1.673

0.731–3.829

0.223

   Tumour size ≥1.5 cmb

2.124

0.792–5.697

0.134

2.594

0.911–7.387

0.074

   Positive lymph node stage

1.973

0.953–4.083

0.067

5.124

2.646–9.924

0.000

   FGFR1 amplification

3.389

1.374–8.358

0.008

1.278

0.450–3.624

0.645

  1. aFitted as a linear term; that is, an increase in risk for change in grade of one unit.
  2. bCompared with tumour size <1.5 cm.