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Table 2 Correlation between FGFR1 gene amplification and the clinicopathological variables
From: FGFR1 amplification in breast carcinomas: a chromogenic in situhybridisation analysis
| Parameter | Number of samples | Positive FGFR1 amplification number (%) | P value |
|---|---|---|---|
| Age | 478 | 0.027 | |
| <50 years | 152 | 7 (4.6) | |
| ≥50 years | 346 | 35 (10.1) | |
| Grade | 478 | Not significant | |
| 1 | 116 | 10 (8.6) | |
| 2 | 141 | 12 (8.5) | |
| 3 | 221 | 20 (9.0) | |
| Size | 478 | Not significant | |
| ≥1.5 cm | 311 | 30 (9.6) | |
| >1.5 cm | 167 | 12 (7.2) | |
| Lymph node stage | 475 | Not significant | |
| N0 | 322 | 28 (8.7) | |
| N1 | 110 | 9 (8.2) | |
| N2 | 43 | 4 (9.3) | |
| Nottingham Prognostic Index | 475 | Not significant | |
| Good | 175 | 14 (8.0) | |
| Moderate | 239 | 21 (8.8) | |
| Poor | 61 | 6 (9.8) | |
| Distant metastasis | 478 | 0.050 | |
| No | 394 | 30 (7.6) | |
| Definite | 84 | 12 (14.3) | |
| Vascular invasion | 467 | Not significant | |
| No | 337 | 27 (8.0) | |
| Yes | 130 | 14 (10.8) | |
| Oestrogen receptor | 453 | Not significant | |
| Negative | 140 | 10 (7.1) | |
| Positive | 313 | 27 (8.6) | |
| Progesterone receptor | 449 | 0.084 | |
| Negative | 206 | 22 (10.7) | |
| Positive | 243 | 15 (6.2) | |
| HER2 | 445 | 0.043 | |
| Negative | 259 | 28 (10.8) | |
| Positive | 186 | 10 (5.4) | |
| Androgen receptor | 415 | Not significant | |
| Negative | 188 | 18 (9.6) | |
| Positive | 227 | 13 (5.7) | |
| Cytokeratin 7/8 | 467 | Not significant | |
| Negative | 167 | 17 (10.2) | |
| Positive | 300 | 24 (8.0) | |
| Cytokeratin 18 | 396 | Not significant | |
| Negative | 116 | 7 (6.0) | |
| Positive | 280 | 23 (8.2) | |
| Cytokeratin 19 | 464 | Not significant | |
| Negative | 95 | 10 (10.5) | |
| Positive | 369 | 30 (8.1) | |
| Cytokeratin 5/6 | 465 | Not significant | |
| Negative | 350 | 34 (9.7) | |
| Positive | 115 | 6 (5.2) | |
| Cytokeratin 14 | 458 | Not significant | |
| Negative | 357 | 33 (9.2) | |
| Positive | 101 | 6 (5.9) | |
| Epidermal growth factor receptor | 351 | Not significant | |
| Negative | 292 | 26 (8.9) | |
| Positive | 59 | 3 (5.1) | |
| Basal markers [27] | 455 | Not significant | |
| Negative | 311 | 31 (10.0) | |
| Positive | 144 | 8 (5.6) | |
| Nielsen groups [28] | 396 | Not significant | |
| HER2 | 39 | 3 (7.7) | |
| Basal-like | 55 | 3 (5.5) | |
| Luminal | 302 | 26 (8.6) |
