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Table 4 Mean percentage mammographic density (MD) according to insulin-like growth factor haplotype-tagging SNPs

From: Common genetic variation in IGF1, IGFBP-1, and IGFBP-3 in relation to mammographic density: a cross-sectional study

SNP Genotype n Mean percentage MDa p for trendb
1 C/C 2 19.1 0.13
  C/T 71 29.5  
  T/T 1,035 26.5  
2 A/A 20 29.1 0.07
  A/G 308 25.0  
  G/G 748 27.4  
3 A/A 51 27.3 0.74
  A/G 388 26.6  
  G/G 662 26.5  
4 A/A 23 25.9 0.89
  A/C 284 26.7  
  C/C 816 26.8  
5 G/G 47 24.7 0.74
  C/G 403 26.6  
  C/C 657 26.8  
6 G/G 88 24.3 0.05
  A/G 419 26.4  
  A/A 569 27.6  
7 A/A 7 20.1 0.007
  A/G 155 24.7  
  G/G 934 27.4  
8 T/T 20 29.3 0.18
  G/T 255 27.9  
  G/G 776 26.4  
9 G/G 36 19.6 <0.0001
  C/G 325 24.8  
  C/C 730 27.9  
10 G/G 19 25.3 0.83
  G/C 262 27.4  
  C/C 809 26.6  
11 A/A 117 23.2 0.0004
  G/A 469 26.4  
  G/G 503 28.2  
12 C/C 59 24.3 0.16
  C/G 425 26.5  
  G/G 605 27.2  
13 G/G 270 27.0 0.60
  A/G 570 26.6  
  A/A 278 26.8  
14 G/G 26 26.1 0.82
  A/G 320 26.3  
  A/A 750 26.9  
  1. aMultivariate-adjusted models including age (continuous), body mass index (continuous), alcohol consumption (category), age at first birth/parity, history of benign breast disease (yes/no), family history of breast cancer (yes/no), menopausal status/postmenopausal hormone use (premenopausal, postmenopausal never user, postmenopausal current user, postmenopausal past user); b p for trend based on inclusion of genotype as an ordinal variable in models with square-root-transformed mammographic density as the dependent variable. Results in bold are significant (p ≤ 0.05).