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Table 3 Common IGFBP-1 and IGFBP-3 haplotypesa and percentage mammographic density, Nurses' Health Study

From: Common genetic variation in IGF1, IGFBP-1, and IGFBP-3 in relation to mammographic density: a cross-sectional study

Block 1 (p = 0.17)b Block 2 (p = 0.11)b Block 3 (p = 0.53)b
Haplotype Frequency (percentage) βc (95% CI) Haplotype Frequency (percentage) βc (95% CI) Haplotype Frequency (percentage) βc (95% CI)
1A (AGCGG) 24.7 -0.12 2A (CACC) 35.5 -0.10 3A (GCTG) 37.0 -0.004
   (-0.29 to 0.04)    (-0.25 to 0.06)    (-0.16 to 0.15)
1B (AGGGG) 22.6 -0.06 2B (CCTC) 27.8 -0.07 3B (AGGT) 20.6 -0.005
   (-0.23 to 0.12)    (-0.23 to 0.08)    (-0.19 to 0.17)
1C (AACGA) 19.5 0.07 2C (CGCC) 17.3 0.17 3C (AGGG) 19.4 0.003
   (-0.11 to 0.25)    (-0.03 to 0.37)    (-0.19 to 0.19)
1D (GGCGA) 18.7 0.20 2D (CGCT) 13.4 0.15 3D (GGGG) 13.0 0.02
   (0.01 to 0.38) d    (-0.06 to 0.37)    (-0.20 to 0.24)
1E (GGCGG) 10.0 -0.05 Rare 6.0 -0.18 3E (GGTG) 6.7 0.18
   (-0.29 to 0.19)    (-0.57 to 0.20)    (-0.12 to 0.48)
Rare 4.5 -     Rare 3.4  
  1. CI, confidence interval; IGFBP, insulin-like growth factor binding protein. aIGFBP1/IGFBP3 haplotype blocks are based on SNPs defined in Table 1. Block 1, SNPs 15 to 19; block 2, SNPs 20 to 23; block 3, SNPs 24 to 27. bGlobal test of association based on F statistic comparing model with haplotypes in block and covariates with covariates only. cβ coefficients from models that used square-root-transformed mammographic density as the dependent variable. Multivariate-adjusted models including age (continuous), body mass index (continuous), alcohol consumption (category), age at first birth/parity, history of benign breast disease (yes/no), family history of breast cancer (yes/no), menopausal status/postmenopausal hormone use (premenopausal, postmenopausal never user, postmenopausal current user, postmenopausal past user). Results in bold show significant differences: d p = 0.04.