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Figure 1 | Breast Cancer Research

Figure 1

From: HER2 therapy. Small molecule HER-2 tyrosine kinase inhibitors

Figure 1

HER-2 containing heterodimers and their downstream signaling effects. Shown are distinct HER-2 containing heterodimers, ligands that activate respective receptor complexes, downstream linked signaling pathways, and their putative functional effects in HER-2 overexpressing breast cancers. AR, amphiregulin; BTC, betacellulin; EGFR, epidermal growth factor receptor; EPR, epiregulin; HB-EGF, heparin-binding epidermal-like growth factor; HER, human epidermal growth factor receptor; MAPK, mitogen-activated protein kinase; NRG, neuregulin; PI3K, phosphatidylinositol-3 kinase; TGF, transforming growth factor.

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