Figure 1From: HER2 therapy. Small molecule HER-2 tyrosine kinase inhibitorsHER-2 containing heterodimers and their downstream signaling effects. Shown are distinct HER-2 containing heterodimers, ligands that activate respective receptor complexes, downstream linked signaling pathways, and their putative functional effects in HER-2 overexpressing breast cancers. AR, amphiregulin; BTC, betacellulin; EGFR, epidermal growth factor receptor; EPR, epiregulin; HB-EGF, heparin-binding epidermal-like growth factor; HER, human epidermal growth factor receptor; MAPK, mitogen-activated protein kinase; NRG, neuregulin; PI3K, phosphatidylinositol-3 kinase; TGF, transforming growth factor.Back to article page