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Table 4 Cytokine levels are correlated to AP-1 expression

From: Oestrogen receptor negative breast cancers exhibit high cytokine content

Biological markers

AP-1 negative (n = 34)

AP-1 positive (n = 69)

P

IL-1β

1.4

(0–11.5)

3.2

(0–260)

0.006

IL-2

0.4

(0–3.2)

1.4

(0–11)

0.001

IL-4

1.1

(0–99.6)

2.7

(0–30.2)

NS

IL-6

12.6

(4.4–70.7)

19.7

(7.8–26,487)

0.001

IL-8

29.6

(0 -778)

115

(1.5–15,890)

0.003

IL-10

0.2

(0–2.6)

0.3

(0– 5.6)

0.004

IL-12 (p70)

1.8

(0 -17.2)

2.7

(0–7.3)

0.044

IL-13

4.2

(3.0–7.2)

4.2

(3.4–394)

NS

G-CSF

17.2

(5.3–87.3)

18.5

(7.1–110)

NS

IFN-γ

25.4

(15.5–55.5)

28.7

(17.1–1,279)

0.002

MCP-1

54.6

(0–1,208)

148

(14.7–37,117)

0.001

MIP-1β

503

(87.2–8,778)

563

(42.6–14,439)

NS

TNF-α

6.9

(6.1–10.9)

7.8

(5.8–121)

0.002

  1. Values are expressed as median (range; fg/μg). AP, activator protein; G-CSF, granulocyte colony-stimulating factor; IL, interleukin; IFN, interferon; MCP, monocyte chemoattractant protein; MIP, macrophage inflammatory protein; NS, not significant; TNF, tumour necrosis factor.