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Table 4 Cytokine levels are correlated to AP-1 expression

From: Oestrogen receptor negative breast cancers exhibit high cytokine content

Biological markers AP-1 negative (n = 34) AP-1 positive (n = 69) P
IL-1β 1.4 (0–11.5) 3.2 (0–260) 0.006
IL-2 0.4 (0–3.2) 1.4 (0–11) 0.001
IL-4 1.1 (0–99.6) 2.7 (0–30.2) NS
IL-6 12.6 (4.4–70.7) 19.7 (7.8–26,487) 0.001
IL-8 29.6 (0 -778) 115 (1.5–15,890) 0.003
IL-10 0.2 (0–2.6) 0.3 (0– 5.6) 0.004
IL-12 (p70) 1.8 (0 -17.2) 2.7 (0–7.3) 0.044
IL-13 4.2 (3.0–7.2) 4.2 (3.4–394) NS
G-CSF 17.2 (5.3–87.3) 18.5 (7.1–110) NS
IFN-γ 25.4 (15.5–55.5) 28.7 (17.1–1,279) 0.002
MCP-1 54.6 (0–1,208) 148 (14.7–37,117) 0.001
MIP-1β 503 (87.2–8,778) 563 (42.6–14,439) NS
TNF-α 6.9 (6.1–10.9) 7.8 (5.8–121) 0.002
  1. Values are expressed as median (range; fg/μg). AP, activator protein; G-CSF, granulocyte colony-stimulating factor; IL, interleukin; IFN, interferon; MCP, monocyte chemoattractant protein; MIP, macrophage inflammatory protein; NS, not significant; TNF, tumour necrosis factor.