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Table 3 Most cytokines are abundant in high-grade tumors

From: Oestrogen receptor negative breast cancers exhibit high cytokine content

Biological markers Grade I (n = 17) Grade II (n = 56) Grade III (n = 32) P
IL-1β 0.8 (0–260) 2.6 (0–102) 4.7 (0–194) 0.025
IL-2 0.9 (0–4.6) 1.2 (0–42.6) 1.4 (0–6.6) NS
IL-4 3.4 (0–20.1) 0.6 (0–30.2) 3.9 (0–99.6) 0.037
IL-6 11.7 (7.8–4,312) 14.1 (4.4–190) 30.6 (8.8–26,487) < 0.001
IL-8 43.9 (9.1–11,281) 35.4 (0–8,358) 186 (0.3–15,890) < 0.001
IL-10 0.2 (0–1.6) 0.2 (0–5.6) 0.7 (0–4.6) 0.030
IL-12 (p70) 1.4 (0–5.3) 2.1 (0–19.3) 2.9 (0.7 -17.2) 0.045
IL-13 4.1 (3.4–21.4) 4.2 (3.0–394) 4.2 (1.6–35.5) NS
G-CSF 13.9 (7.1–87.3) 18.9 (5.3–110) 22.2 (9.9–79.2) NS
IFN-γ 26.8 (19.8–270) 25.6 (17.1–1,279) 28.7 (15.5–324) NS
MCP-1 96.3 (22.8–1,208) 91.3 (0–22,451) 201 (24.4–37,117) 0.006
MIP-1β 451 (44.6–2,674) 496 (42.6–14,439) 776 (114–13,287) 0.011
TNF-α 7.15 (5.9–28.0) 7.1 (5.8–120) 7.8 (6.2–37.2) NS
  1. Values are expressed as median (range; fg/μg). G-CSF, granulocyte colony-stimulating factor; IL, interleukin; IFN, interferon; MCP, monocyte chemoattractant protein; MIP, macrophage inflammatory protein; NS, not significant; TNF, tumour necrosis factor.