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Figure 7 | Breast Cancer Research

Figure 7

From: Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells

Figure 7

T-oligo affects adriamycin resistant breast cancer cells. (a) Unlike MCF-7 cells, Adr/MCF-7 cells proliferate in the presence of adriamycin. (b) Supplementation with T-oligo on day 0 decreased Adr/MCF-7 cell yields in both the presence and absence of adriamycin for at least 96 hours (58% ± 14%, p < 0.03, n = 4). (b) T-oligo also increased the percent of cells in the S phase within 48 hours and through 96 hours (p < 0.04, n = 2) and (d) induced apoptosis as determined by TUNEL analysis at 96 hours. (e) T-oligo induced the phosphorylation of p53 and H2AX comparably to MCF-7 cells (Figure 5a). C, control-oligo; D, diluent; T, T-oligo.

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