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Table 3 VDR genotype and postmenopausal breast cancer risk stratified by total calcium and vitamin D intakesa

From: Vitamin D pathway gene polymorphisms, diet, and risk of postmenopausal breast cancer: a nested case-control study

  Total calcium (mg/day) Total vitamin D (IU/day)
  <902 902+ <222 222+
SNP OR 95% CI OR 95% CI OR 95% CI OR 95% CI
Fok 1         
   FF 1.00 - 0.91 (0.56–1.47) 1.00 - 0.89 (0.55–1.45)
   Ff 0.79 (0.50–1.25) 0.80 (0.50–1.26) 0.72 (0.45–1.14) 0.88 (0.56–1.39)
   ff 1.08 (0.56–2.09) 0.63 (0.32–1.24) 1.03 (0.53–1.99) 0.68 (0.36–1.29)
  p interaction = 0.34b p interaction = 0.18
Taq1         
   tt or Tt 1.00 - 1.16 (0.81–1.65) 1.00 - 1.02 (0.70–1.49)
   TT 1.24 (0.79–1.94) 0.64 (0.41–0.99) 0.88 (0.56–1.38) 0.77 (0.50–1.21)
  p interaction = 0.01 p interaction = 0.36
Apa1         
   AA 1.00 - 0.86 (0.49–1.50) 1.00 - 0.86 (0.48–1.53)
   Aa or aa 0.86 (0.53–1.38) 0.74 (0.47–1.17) 0.77 (0.49–1.20) 0.82 (0.52–1.31)
  p interaction = 0.77 p interaction = 0.47
Bsm1         
   BB or Bb 1.00 - 1.05 (0.71–1.55) 1.00 - 0.90 (0.60–1.35)
   bb 1.20 (0.73–1.95) 0.61 (0.38–0.96) 0.72 (0.44–1.18) 0.78 (0.49–1.26)
  p interaction = 0.01 p interaction = 0.90
Poly(A) tail         
   SS or SL 1.00 - 1.16 (0.81–1.67) 1.00 - 0.96 (0.66–1.41)
   LL 1.18 (0.74–1.87) 0.66 (0.42–1.04) 0.79 (0.50–1.26) 0.77 (0.49–1.21)
  p interaction = 0.02 p interaction = 0.72
  1. aMultivariate adjusted models contain the SNP, dietary exposure, and interaction term and adjust for body mass index, history of breast cyst, hormone replacement therapy use, family history of breast cancer, education, parity and age at first birth combined, age at menarche, age at menopause, and total energy intake. bInteraction terms were created using continuous form of dietary variables. CI, confidence interval; OR, odds ratio; SNP, single-nucleotide polymorphism; VDR, vitamin D receptor.