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Table 2 Associations between SNPs in VDR, GC, and CYP24A1 genes and postmenopausal breast cancer riska

From: Vitamin D pathway gene polymorphisms, diet, and risk of postmenopausal breast cancer: a nested case-control study

  Frequency Matched only Multivariate-adjustedb
SNP Cases Controls (%) OR 95% CI OR 95% CI
VDR       
Fok1 (rs2228570)
   FF 191 185 (37.0) 1.00 - 1.00 -
   Ff 207 227 (45.4) 0.89 (0.68–1.17) 0.78 (0.58–1.05)
   ff 77 68 (13.6) 1.11 (0.75–1.63) 0.98 (0.65–1.50)
Taq1 (rs731236)
   tt or Tt 336 312 (62.4) 1.00 - 1.00 -
   TT 158 180 (36.0) 0.82 (0.63–1.06) 0.83 (0.62–1.12)
Apa1 (rs7975232)
   AA 147 129 (25.8) 1.00 - 1.00 -
   Aa or aa 341 348 (69.6) 0.87 (0.65–1.15) 0.87 (0.64–1.18)
Bsm1 (rs1544410)
   BB or Bb 321 290 (58.0) 1.00 - 1.00 -
   bb 151 170 (34.0) 0.81 (0.61–1.06) 0.84 (0.62–1.15)
Poly(A) tail
   SS or SL 328 304 (60.8) 1.00 - 1.00 -
   LL 158 177 (35.4) 0.83 (0.63–1.08) 0.83 (0.61–1.12)
GC protein (rs4588)
   C/C 240 246 (51.7) 1.00 - 1.00 -
   A/C 202 186 (39.1) 1.11 (0.84–1.45) 1.11 (0.82–1.48)
   A/A 48 44 (9.2) 1.13 (0.73–1.76) 1.30 (0.80–2.13)
GC protein (rs7041)
   G/G 154 149 (30.4) 1.00 - 1.00 -
   G/T 237 235 (48.0) 0.98 (0.72–1.33) 0.94 (0.67–1.31)
   T/T 103 106 (21.6) 0.94 (0.66–1.33) 0.96 (0.65–1.41)
CYP24A1 (rs2296241)
   A/A 141 139 (28.4) 1.00 - 1.00 -
   A/G 254 253 (51.6) 0.99 (0.74–1.31) 1.03 (0.75–1.41)
   G/G 99 98 (20.0) 1.00 (0.70–1.43) 1.05 (0.71–1.56)
  1. aAll models contain a variable for unknown SNP genotype which is not presented. bModels are adjusted for body mass index, history of breast cyst, hormone replacement therapy use, family history of breast cancer, education, parity and age at first birth combined, age at menarche, and age at menopause. CI, confidence interval; GC, group-specific component; OR, odds ratio; SNP, single-nucleotide polymorphism; VDR, vitamin D receptor.