Table 2 Associations between SNPs in VDR, GC, and CYP24A1 genes and postmenopausal breast cancer riska
Frequency | Matched only | Multivariate-adjustedb | ||||
|---|---|---|---|---|---|---|
SNP | Cases | Controls (%) | OR | 95% CI | OR | 95% CI |
VDR | ||||||
Fok1 (rs2228570) | ||||||
FF | 191 | 185 (37.0) | 1.00 | - | 1.00 | - |
Ff | 207 | 227 (45.4) | 0.89 | (0.68–1.17) | 0.78 | (0.58–1.05) |
ff | 77 | 68 (13.6) | 1.11 | (0.75–1.63) | 0.98 | (0.65–1.50) |
Taq1 (rs731236) | ||||||
tt or Tt | 336 | 312 (62.4) | 1.00 | - | 1.00 | - |
TT | 158 | 180 (36.0) | 0.82 | (0.63–1.06) | 0.83 | (0.62–1.12) |
Apa1 (rs7975232) | ||||||
AA | 147 | 129 (25.8) | 1.00 | - | 1.00 | - |
Aa or aa | 341 | 348 (69.6) | 0.87 | (0.65–1.15) | 0.87 | (0.64–1.18) |
Bsm1 (rs1544410) | ||||||
BB or Bb | 321 | 290 (58.0) | 1.00 | - | 1.00 | - |
bb | 151 | 170 (34.0) | 0.81 | (0.61–1.06) | 0.84 | (0.62–1.15) |
Poly(A) tail | ||||||
SS or SL | 328 | 304 (60.8) | 1.00 | - | 1.00 | - |
LL | 158 | 177 (35.4) | 0.83 | (0.63–1.08) | 0.83 | (0.61–1.12) |
GC protein (rs4588) | ||||||
C/C | 240 | 246 (51.7) | 1.00 | - | 1.00 | - |
A/C | 202 | 186 (39.1) | 1.11 | (0.84–1.45) | 1.11 | (0.82–1.48) |
A/A | 48 | 44 (9.2) | 1.13 | (0.73–1.76) | 1.30 | (0.80–2.13) |
GC protein (rs7041) | ||||||
G/G | 154 | 149 (30.4) | 1.00 | - | 1.00 | - |
G/T | 237 | 235 (48.0) | 0.98 | (0.72–1.33) | 0.94 | (0.67–1.31) |
T/T | 103 | 106 (21.6) | 0.94 | (0.66–1.33) | 0.96 | (0.65–1.41) |
CYP24A1 (rs2296241) | ||||||
A/A | 141 | 139 (28.4) | 1.00 | - | 1.00 | - |
A/G | 254 | 253 (51.6) | 0.99 | (0.74–1.31) | 1.03 | (0.75–1.41) |
G/G | 99 | 98 (20.0) | 1.00 | (0.70–1.43) | 1.05 | (0.71–1.56) |