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Table 1 Cancer-related functions and interrelation of Sdc1, c-met and E-cad

From: An expression signature of syndecan-1 (CD138), E-cadherin and c-met is associated with factors of angiogenesis and lymphangiogenesis in ductal breast carcinoma in situ

Marker

Molecular characteristics

Biological functions relevant to cancera

Clinical relevance to breast cancera

Relation to c-meta

Relation to E-cada

Sdc1

Cell surface heparan sulphate proteoglycan

Cell and matrix receptor [1]

Coreceptor for chemokines, angiogenic and growth factors, and modulator of proteolytic activity [2-4,16,57]

Positive correlation with poor prognosis and tumour angiogenesis [6-8,33]

Predictive factor in neoadjuvant chemotherapy [9]

Sdc1 is c-met co-receptor in multiple myeloma [10]

Coordinated regulation and codistribution in mammary tumor cells and epithelial-mesenchymal transition [22-25]

β-Catenin responsive progenitor cells depend on Sdc1 [27,28]

c-met

Transmembrane tyrosine kinase receptor for hepatocyte growth factor

c-met pathway modulates cell dissociation and motility, protease overexpression and stimulates angiogenesis [11,12]

Expression associated with poor outcome in patients with (axillary) lymph node negative breast cancer [15,47,70]

Negative prognostic factor in breast cancer [71,72]

Not applicable

Correlation with abnormal β-catenin expression suggests downregulation of E-cad/β-catenin by c-met [73]

E-cad

Epithelial calcium-dependent cell adhesion molecule

Ensures structural integrity, and contact inhibition of epithelia [21]

Expression changes during epithelial-mesenchymal transition [40]

Involved in β-catenin-mediated signalling [20]

Membranous staining is independent predictor for disease-free survival in lobular breast cancer [44]

Loss of expression is associated with negative ER status, high histological grade, metastasis and poor prognosis in breast cancer [43,45,46,74,75]

E-cad is used to distinguish ductal from lobular neopasia [18,19]

(See Sdc1)

Not applicable

  1. aSelected examples are given, along with references. E-cad, E-cadherin; ER, oestrogen receptor; Sdc, syndecan.