Genotype | Characteristics | |||||||
---|---|---|---|---|---|---|---|---|
Tumour size (mm)a | Tumour stage | Nodal involvement | ||||||
≤20 | 21–50 | >50 | II | III | 0 | 1–3 | >4 | |
CYP3A5 (n = 663) | n (%) | n (%) | n (%) | |||||
*1/*1 | 1 (14.3) | 5 (71.4) | 1 (14.3) | 6 (85.7) | 1 (14.3) | 3 (42.9) | 3 (42.9) | 1 (14.3) |
*1/*3 | 28 (30.4) | 59 (64.1) | 5 (5.4) | 83 (89.2) | 10 (10.8) | 27 (29.0) | 45 (48.4) | 21 (22.6) |
*3/*3 | 150 (26.8) | 369 (66.0) | 40 (7.2) | 479 (85.1) | 84 (14.9) | 177 (31.4) | 220 (39.1) | 166 (29.5) |
P | 0.78 | 0.57 | 0.40 | |||||
CYP2D6 (n = 677) | ||||||||
*1/*1 | 132 (28.9) | 294 (64.3) | 31 (6.8) | 393 (85.4) | 67 (14.6) | 142 (30.9) | 194 (42.2) | 124 (27.0) |
*1/*4 | 45 (24.7) | 125 (66.7) | 12 (6.6) | 159 (86.9) | 24 (13.1) | 56 (30.6) | 73 (39.9) | 54 (29.5) |
*4/*4 | 9 (27.3) | 21 (63.6) | 3 (9.1) | 29 (85.3) | 5 (14.7) | 10 (29.4) | 14 (41.2) | 10 (29.4) |
P | 0.83 | 0.89 | 0.98 | |||||
SULT1A1 (n = 677) | ||||||||
*1/*1 | 77 (30.5) | 163 (64.7) | 12 (4.8) | 223 (88.1) | 30 (11.9) | 80 (31.6) | 104 (41.1) | 69 (27.3) |
*1/*2 | 79 (25.0) | 209 (66.1) | 28 (8.9) | 269 (84.3) | 50 (15.7) | 85 (26.6) | 142 (44.5) | 92 (28.8) |
*2/*2 | 30 (28.8) | 68 (65.4) | 6 (5.8) | 89 (84.8) | 16 (15.2) | 43 (41.0) | 35 (33.3) | 27 (25.7) |
P | 0.26 | 0.41 | 0.09 | |||||
UGT2B15 (n = 445) | ||||||||
*1/*1 | 38 (31.6) | 71 (59.2) | 11 (9.2) | 99 (82.5) | 21 (17.5) | 41 (34.2) | 41 (34.2) | 38 (31.6) |
*1/*2 | 46 (24.9) | 129 (69.7) | 10 (5.4) | 160 (85.6) | 27 (14.4) | 58 (31.0) | 75 (40.1) | 54 (28.9) |
*2/*2 | 40 (29.2) | 82 (59.9) | 15 (10.9) | 110 (79.7) | 28 (20.3) | 37 (26.8) | 68 (49.3) | 33 (23.9) |
P | 0.18 | 0.38 | 0.18 |