TY - JOUR AU - Wegman, Pia AU - Elingarami, Sauli AU - Carstensen, John AU - Stål, Olle AU - Nordenskjöld, Bo AU - Wingren, Sten PY - 2007 DA - 2007/01/23 TI - Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer JO - Breast Cancer Research SP - R7 VL - 9 IS - 1 AB - Tamoxifen therapy reduces the risk of recurrence and prolongs the survival of oestrogen-receptor-positive patients with breast cancer. Even if most patients benefit from tamoxifen, many breast tumours either fail to respond or become resistant. Because tamoxifen is extensively metabolised by polymorphic enzymes, one proposed mechanism underlying the resistance is altered metabolism. In the present study we investigated the prognostic and/or predictive value of functional polymorphisms in cytochrome P450 3A5 CYP3A5 (*3), CYP2D6 (*4), sulphotransferase 1A1 (SULT1A1; *2) and UDP-glucuronosyltransferase 2B15 (UGT2B15; *2) in tamoxifen-treated patients with breast cancer. SN - 1465-542X UR - https://doi.org/10.1186/bcr1640 DO - 10.1186/bcr1640 ID - Wegman2007 ER -