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Table 3 PTGS2 haplotypes and breast cancer risk in the Nurses' Health Study

From: A polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control study

Haplotype Cases (percentage) Controls (percentage) OR (95% CI)a
z1 G-G-T-T-A 1,250 (49.4) 1,691 (48.2) 1.00 (reference)
z2 G-G-T-C-A 435 (17.2) 667 (19.0) 0.84 (0.72–0.98)
z3 G-C-T-T-A 403 (15.9) 544 (15.5) 0.99 (0.85–1.17)
z4 C-G-G-C-A 358 (14.1) 507 (14.5) 0.92 (0.79–1.09)
z5 C-G-G-C-G 53 (2.1) 63 (1.8) 1.16 (0.78–1.72)
    Global p = 0.15
  1. aUnconditional logistic regression controlled for age, BMI at age 18 years, menopausal status at diagnosis, history of benign breast disease, and family history of breast cancer. CI, confidence interval; OR, odds ratio; PTGS2, prostaglandin endoperoxide synthase 2.