|
SNP
|
Genotype
|
Cases (percentage)
|
Controls (percentage)
|
OR (95% CI)a
|
|---|
|
PTGS2_20417
|
G/G
|
865 (69.6)
|
1,185 (69.1)
|
1.00 (reference)
|
| |
G/C
|
336 (27.0)
|
485 (28.3)
|
0.93 (0.78–1.10)
|
| |
C/C
|
42 (3.4)
|
45 (2.6)
|
1.28 (0.82–2.02)
|
| | | | |
p trend = 0.94
|
|
PTGS2_5277
|
G/G
|
875 (71.0)
|
1,217 (71.0)
|
1.00 (reference)
|
| |
G/C
|
322 (26.1)
|
464 (27.1)
|
1.00 (0.84–1.19)
|
| |
C/C
|
35 (2.8)
|
34 (2.0)
|
1.35 (0.81–2.26)
|
| | | | |
p trend = 0.55
|
|
PTGS2_5209
|
T/T
|
834 (69.4)
|
1,171 (69.5)
|
1.00 (reference)
|
| |
T/G
|
330 (27.5)
|
472 (28.0)
|
0.97 (0.82–1.16)
|
| |
G/G
|
38 (3.2)
|
43 (2.6)
|
1.24 (0.77–2.00)
|
| | | | |
p trend = 0.81
|
|
PTGS2_5275
|
T/T
|
541 (43.3)
|
699 (40.6)
|
1.00 (reference)
|
| |
T/C
|
567 (45.4)
|
808 (47.0)
|
0.88 (0.75–1.04)
|
| |
C/C
|
141 (11.3)
|
213 (12.4)
|
0.80 (0.62–1.03)
|
| | | | |
p trend = 0.05
|
|
PTGS2_4648298
|
A/A
|
1,180 (95.4)
|
1,654 (96.3)
|
1.00 (reference)
|
| |
A/G + G/G
|
57 (4.6)
|
63 (3.7)
|
1.29 (0.88–1.88)
|
-
aUnconditional logistic regression controlled for age, BMI at age 18 years, menopausal status at diagnosis, history of benign breast disease, and family history of breast cancer. CI, confidence interval; PTGS2, prostaglandin endoperoxide synthase 2; OR, odds ratio; SNP, single-nucleotide polymorphism.
