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Table 1 Perinatal lethality, fertility, and lactation defect in SirT1ko/ko mice

From: SirT1 modulates the estrogen–insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice

Parents

Pups

Male

Female

Litter

Survivorsa

+/+

+/ko

ko/ko

+/ko

+/ko

47

340

101

208

31

ko/ko (n = 3)

+/ko

11

55

-

45

10

+/ko

ko/ko (n = 5)

8

0

-

(13)

(13)

  1. More than 10 pairs of SirT1+/ko male mice and SirT1+/ko female mice were used for breeding. Data in parentheses indicate the number of pups of this genotype found dead within 3 days after their birth. aTotal number of surviving pups at weaning (postnatal day 21).