Analysis of Epstein-Barr virus reservoirs in paired blood and breast cancer primary biopsy specimens by real time PCR

Table 2 Analysis of the concentration of EBV in matched blood and tumor specimens

Category	Peripheral blood-/tumor-	Peripheral blood+/tumor+	Peripheral blood+/tumor-	Peripheral blood-/tumor+
Number (percentage of total)^a	10 (42)	7 (29)	3 (12)	4 (17)
Ratio of EBV genomes^b in blood versus tumor (range of EBV levels in peripheral blood)	0.0	5.0 (0.6–22.0)	Undefined	Undefined
Range of EBV levels^c in peripheral blood	0.0	8.0 (2.0–22.0)	4 (1.0–8.0)	0.0
Range of EBV levels^c in tumor specimens	0.0	5.0 (1–14)	0.0	1.0 (1.0–2.0)

^a N = 24. ^bThe number of Epstein-Barr virus (EBV) genomes was determined in 160,000 cell equivalents of DNA isolated from peripheral blood and tumor specimens. ^cRange (highest level to lowest level of EBV genomes in the peripheral blood).

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