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Table 3 Agreement among methods for measuring HER2

From: Molecular subtypes of breast cancer in relation to paclitaxel response and outcomes in women with metastatic disease: results from CALGB 9342

Method Cohen's kappa Sensitivity Specificity
FISH versus CB11 83.0% (SE 5.3%) 97% 93%
HercepTest versus FISH    
   (0–1 versus 2–3) versus FISH 72.0% (SE 6.2%) 92% 87%
   (0–2 versus 3) versus FISH 79.2% (SE 6.0%) 78% 97%
HercepTest versus CB11    
   (0–1 versus 2–3) versus CB11 70.0% (SE 6.3%) 100% 85%
   (0–2 versus 3) versus CB11 84.2% (SE 5.4%) 90% 96%
  1. FISH, fluorescent in situ hybridization; SE, standard error for Cohen's kappa.