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Table 4 List of 43 genes able to discriminate between well- and poorly differentiated DCIS

From: Classification of ductal carcinoma in situ by gene expression profiling

Rank

NKI ID

Symbol

Annotation

Accession no.

1

108691

ACK1

Activated p21cdc42Hs kinase

AA427891

2

109246

BCL2

B-cell CLL/lymphoma 2

W63749

3

109268

ALDH3A2

Aldehyde dehydrogenase 3 family, member A2

AA633569

4

109236

BTD

Biotinidase

R17765

5

108595

CCL19

Small inducible cytokine subfamily A (Cys-Cys), member 19

AA680186

6

100524

CELSR2

Cadherin, EGF LAG seven-pass G-type receptor 2, flamingo (Drosophila) homolog

H39187

7

126868

TMC4

DKFZP586J0619 protein

AA991211

8

100708

SLC39A6

LIV-1 protein, oestrogen regulated

H29315

9

109170

C4A

Complement component 4A

AA664406

10

109127

ESR1

Oestrogen receptor 1

AA291749

11

128702

 

EST

AI313031

12

121012

HSHIN1

Hin-1

AA902831

13

128095

PCSK6

Paired basic amino acid cleaving system 4

W85807

14

128052

ARHGEF7

PAK-interacting exchange factor beta

AA452871

15

128493

GMFG

Glia maturation factor, gamma

AI311932

16

123382

HIG1

Likely ortholog of mouse hypoxia induced gene 1

T74105

17

129689

C1orf21

Chromosome 1 open reading frame 21

AA406569

18

102289

ETFA

Electron-transfer-flavoprotein, alpha polypeptide (glutaric aciduria II)

T57919

19

126124

FLJ20152

Hypothetical protein

AA918685

20

127815

PLAT

Plasminogen activator, tissue

R38933

21

101559

NPY1R

Neuropeptide Y receptor Y1

R43817

22

100260

MAL

Mal, T-cell differentiation protein

AA227885

23

127969

CRYAA

Crystallin, alpha A

H84722

24

128244

SERPINA3

Serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3

AA704242

25

108649

 

Human clone 23948 mRNA sequence

H15114

26

106399

GRTP1

Hypothetical protein FLJ22474

N52651

27

123478

FLJ14712

Hypothetical protein FLJ14712

N79050

28

117207

EMP3

Epithelial membrane protein 3

W73810

29

111787

ZNF451

H. sapiens cDNA FLJ13010 fis, clone NT2RP3000542

AA486412

30

109502

KITLG

H. sapiens cDNA: FLJ21592 fis, clone COL07036

H11088

31

109315

UCP2

Uncoupling protein 2 (mitochondrial, proton carrier)

H61243

32

118532

NUPL1

PRO2463 protein

AA772502

33

100263

MYB

V-myb avian myeloblastosis viral oncogene homolog

N49284

34

128249

CD3E

CD3E antigen, epsilon polypeptide (TiT3 complex)

AA933862

35

131226

IL7R

Interleukin 7 receptor

T65739

36

100104

SELL

Selectin L (lymphocyte adhesion molecule 1)

H00662

37

108671

BCAT2

Branched chain aminotransferase 2, mitochondrial

AA436410

38

116984

ATP5B

ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide

AA708298

39

108376

LAMA3

Laminin, alpha 3 (nicein [150 kD], kalinin [165 kD], BM600 [150 kD], epilegrin)

AA001432

40

104944

SLC7A2

Solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

R26163

41

100840

THOC1

Nuclear matrix protein p84

AA129297

42

100650

SHFM1

Deleted in split-hand/split-foot 1 region

H85464

43

101429

SIAT1

Sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase)

AA598652

  1. DCIS, ductal carcinoma in situ; EST, expressed sequence tag; NKI ID, Netherlands Cancer Institute (Amsterdam, The Netherlands) identification number.