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Figure 1 | Breast Cancer Research

Figure 1

From: Presence of apoptotic and nonapoptotic disseminated tumor cells reflects the response to neoadjuvant systemic therapy in breast cancer

Figure 1

Disseminated apoptotic and nonapoptotic disseminated tumor cells. (a) Nonapoptotic disseminated tumor cell (DTC) (detected by the APAAP kit method). (b) Apoptotic DTC identified by M30 staining and morphological assessment (for example, membrane blebbing, nuclear shrinkage) (APAAP kit detection method). (c) Apoptotic DTC identified by morphological assessment (nuclear shrinkage, cytokeratin inclusions) (DTC detected by a fluorescein-5-isothiocyanate-labeled anticytokeratin antibody). (d) Apoptotic cell body without detectable amounts of chromatin.

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