Figure 8
From: Gene expression signatures of morphologically normal breast tissue identify basal-like tumors
Heatmap of a cancer dataset [8] clustered using the normal gene signature. This signature identifies a distinct cluster of 38 estrogen receptor (ER)/progesterone receptor (PR) negative, HER2 negative samples corresponding to the basal breast cancer subtype [35]. Elevated expression of normal stroma-specific genes appears in a portion of the lumenal and HER2 positive tumors, although this expression does not correlate with the known molecular subtypes of breast cancer.