Parameter | Total | Preserved expression | |||||
---|---|---|---|---|---|---|---|
 |  | TIMP-3 within cancer cells | Fibroblastic TIMP-3 | ||||
 |  | n | % | p | n | % | p |
Menopausal status | Â | Â | Â | Â | Â | Â | Â |
   Before | 52 | 19 | 36.5 | NS | 25 | 48.1 | NS |
   After | 115 | 41 | 35.7 |  | 53 | 46.1 |  |
Histological type | Â | Â | Â | Â | Â | Â | Â |
   Ductal | 133 | 46 | 34.6 | NS | 61 | 45.9 | NS |
   Lobular | 33 | 14 | 42.4 |  | 17 | 51.5 |  |
Histological grade | Â | Â | Â | Â | Â | Â | Â |
   1 | 21 | 12 | 57.1 | 0.015 | 12 | 54.5 | NS |
   2 | 98 | 36 | 36.7 |  | 44 | 44.9 |  |
   3 | 43 | 9 | 20.9 |  | 19 | 44.2 |  |
Nuclear grade | Â | Â | Â | Â | Â | Â | Â |
   1 | 58 | 28 | 48.3 | 0.032 | 27 | 46.6 | NS |
   2 | 55 | 19 | 34.5 |  | 25 | 44.6 |  |
   3 | 53 | 13 | 24.5 |  | 26 | 49.1 |  |
Tumor size | Â | Â | Â | Â | Â | Â | Â |
   <2 | 39 | 19 | 48.7 | NS | 20 | 51.3 | NS |
   2 to 5 | 101 | 35 | 34.7 |  | 43 | 42.2 |  |
   >5 | 26 | 6 | 23.1 |  | 15 | 57.7 |  |
LN status | Â | Â | Â | Â | Â | Â | Â |
   Not infiltrated | 65 | 24 | 36.9 | NS | 30 | 45.5 | NS |
   Infiltrated | 100 | 36 | 36.0 |  | 48 | 48.0 |  |
Stage | Â | Â | Â | Â | Â | Â | Â |
   1 | 29 | 13 | 44.8 | NS | 15 | 51.7 | NS |
   2 | 108 | 40 | 37.0 |  | 47 | 43.1 |  |
   3 | 28 | 7 | 25.0 |  | 16 | 57.1 |  |
ER status | Â | Â | Â | Â | Â | Â | Â |
   Negative | 75 | 21 | 28.0 | 0.053 | 35 | 46.7 | NS |
   Positive | 91 | 39 | 42.9 |  | 43 | 46.7 |  |
PR status | Â | Â | Â | Â | Â | Â | Â |
   Negative | 84 | 28 | 33.3 | NS | 40 | 47.6 | NS |
   Positive | 82 | 32 | 39.0 |  | 38 | 45.8 |  |
p53 status | Â | Â | Â | Â | Â | Â | Â |
   Negative | 118 | 51 | 43.2 | 0.002 | 57 | 47.9 | NS |
   Positive | 46 | 8 | 17.4 |  | 19 | 41.3 |  |
Bcl-2 status | Â | Â | Â | Â | Â | Â | Â |
   Negative | 54 | 16 | 29.6 | 0.02 | 29 | 53.7 | NS |
   Positive | 79 | 40 | 50.6 |  | 41 | 51.3 |  |
c-erbB-2 status | Â | Â | Â | Â | Â | Â | Â |
   Negative | 62 | 18 | 29.0 | NS | 25 | 39.7 | NS |
   Positive | 104 | 42 | 40.4 |  | 53 | 51.0 |  |