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Table 1 Correlation of TIMP-3 protein expression with clinicopathological parameters and various biological markers.

From: Expression of tissue inhibitor of matrix metalloproteinases (TIMP)-3 protein in invasive breast carcinoma: Relation to tumor phenotype and clinical outcome

Parameter

Total

Preserved expression

  

TIMP-3 within cancer cells

Fibroblastic TIMP-3

  

n

%

p

n

%

p

Menopausal status

       

   Before

52

19

36.5

NS

25

48.1

NS

   After

115

41

35.7

 

53

46.1

 

Histological type

       

   Ductal

133

46

34.6

NS

61

45.9

NS

   Lobular

33

14

42.4

 

17

51.5

 

Histological grade

       

   1

21

12

57.1

0.015

12

54.5

NS

   2

98

36

36.7

 

44

44.9

 

   3

43

9

20.9

 

19

44.2

 

Nuclear grade

       

   1

58

28

48.3

0.032

27

46.6

NS

   2

55

19

34.5

 

25

44.6

 

   3

53

13

24.5

 

26

49.1

 

Tumor size

       

   <2

39

19

48.7

NS

20

51.3

NS

   2 to 5

101

35

34.7

 

43

42.2

 

   >5

26

6

23.1

 

15

57.7

 

LN status

       

   Not infiltrated

65

24

36.9

NS

30

45.5

NS

   Infiltrated

100

36

36.0

 

48

48.0

 

Stage

       

   1

29

13

44.8

NS

15

51.7

NS

   2

108

40

37.0

 

47

43.1

 

   3

28

7

25.0

 

16

57.1

 

ER status

       

   Negative

75

21

28.0

0.053

35

46.7

NS

   Positive

91

39

42.9

 

43

46.7

 

PR status

       

   Negative

84

28

33.3

NS

40

47.6

NS

   Positive

82

32

39.0

 

38

45.8

 

p53 status

       

   Negative

118

51

43.2

0.002

57

47.9

NS

   Positive

46

8

17.4

 

19

41.3

 

Bcl-2 status

       

   Negative

54

16

29.6

0.02

29

53.7

NS

   Positive

79

40

50.6

 

41

51.3

 

c-erbB-2 status

       

   Negative

62

18

29.0

NS

25

39.7

NS

   Positive

104

42

40.4

 

53

51.0

 
  1. ER, estrogen receptor; LN, lymph node; NS, not significant; PR, progesterone receptor; TIMP, tissue inhibitor of metalloproteinases.