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Table 4 Adjusted means of absolute mammographic densitya (95% confidence interval) in quartiles of plasma leptin concentration, stratified by tertiles of nondense mammographic area (n = 967)

From: Plasma levels of leptin and mammographic density among postmenopausal women: a cross-sectional study

Nondense mammographic area Quartile of plasma leptin concentration P trend
  <9.1 ng/ml 9.1–14.5 ng/ml 14.6–24.0 ng/ml >24.0 ng/ml  
First tertile (n) 140 90 55 40  
   Mammographic density, adjustedb 19.1(16.2–22.6) 17.8 (14.7–21.5) 16.8 (13.5–20.9) 19.4 (15.0–25.2) 0.7
   Mammographic density, adjustedb, additionally adjusted for BMIc 22.1 (18.2–26.8) 19.0 (15.6–23.1) 17.5 (14.0–21.9) 18.7 (14.4–24.3) 0.12
Second tertile (n) 68 82 94 75  
   Mammographic density, adjustedb 10.6 (7.8–14.5) 14.1(10.4–19.1) 13.2 (10.1–17.4) 17.3 (13.1–22.8) 0.02
   Mammographic density, adjustedb, additionally adjusted for BMIc 9.9 (7.2–13.6) 14.0 (10.3–19.0) 13.7 (10.3–18.2) 19.6 (14.6–26.3) 0.003
Third tertile (n) 43 62 94 124  
   Mammographic density, adjustedb 7.5 (4.9–11.6) 10.4 (7.2–15.0) 6.2 (4.5–8.5) 7.0 (5.2–9.4) 0.22
   Mammographic density, adjustedb, additionally adjusted for BMIc 8.2 (5.1–13.1) 11.3 (7.7–16.7) 7.5 (5.1–10.9) 8.6 (5.9–12.5) 0.63
  1. aMultiple linear regression. Absolute mammographic density was log-transformed, reported means are back-transformed.
  2. bAdjusted for age (tertiles), full-term pregnancies (none, 1–2, 3, >3), age at first birth (<20 years, 20–24 years, >24 years) and postmenopausal hormone therapy (current use/noncurrent use).
  3. cBody mass index (BMI), <23, 23–24, 25–26, 27–28, >28.