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Table 4 Adjusted means of absolute mammographic densitya (95% confidence interval) in quartiles of plasma leptin concentration, stratified by tertiles of nondense mammographic area (n = 967)

From: Plasma levels of leptin and mammographic density among postmenopausal women: a cross-sectional study

Nondense mammographic area

Quartile of plasma leptin concentration

P trend

 

<9.1 ng/ml

9.1–14.5 ng/ml

14.6–24.0 ng/ml

>24.0 ng/ml

 

First tertile (n)

140

90

55

40

 

   Mammographic density, adjustedb

19.1(16.2–22.6)

17.8 (14.7–21.5)

16.8 (13.5–20.9)

19.4 (15.0–25.2)

0.7

   Mammographic density, adjustedb, additionally adjusted for BMIc

22.1 (18.2–26.8)

19.0 (15.6–23.1)

17.5 (14.0–21.9)

18.7 (14.4–24.3)

0.12

Second tertile (n)

68

82

94

75

 

   Mammographic density, adjustedb

10.6 (7.8–14.5)

14.1(10.4–19.1)

13.2 (10.1–17.4)

17.3 (13.1–22.8)

0.02

   Mammographic density, adjustedb, additionally adjusted for BMIc

9.9 (7.2–13.6)

14.0 (10.3–19.0)

13.7 (10.3–18.2)

19.6 (14.6–26.3)

0.003

Third tertile (n)

43

62

94

124

 

   Mammographic density, adjustedb

7.5 (4.9–11.6)

10.4 (7.2–15.0)

6.2 (4.5–8.5)

7.0 (5.2–9.4)

0.22

   Mammographic density, adjustedb, additionally adjusted for BMIc

8.2 (5.1–13.1)

11.3 (7.7–16.7)

7.5 (5.1–10.9)

8.6 (5.9–12.5)

0.63

  1. aMultiple linear regression. Absolute mammographic density was log-transformed, reported means are back-transformed.
  2. bAdjusted for age (tertiles), full-term pregnancies (none, 1–2, 3, >3), age at first birth (<20 years, 20–24 years, >24 years) and postmenopausal hormone therapy (current use/noncurrent use).
  3. cBody mass index (BMI), <23, 23–24, 25–26, 27–28, >28.