Plasma levels of leptin and mammographic density among postmenopausal women: a cross-sectional study

Breast Cancer Research

Table 3 Unadjusted and adjusted means of mammographic density (95% confidence interval) in quartiles of plasma leptin concentration^a (n = 967)

	Quartile of plasma leptin concentration				P _trend
	<9.1 ng/ml	9.1–14.5 ng/ml	14.6–24.0 ng/ml	>24.0 ng/ml
n	251	234	243	239
Absolute mammographic density (cm²)
Unadjusted	13.8 (11.9–16.0)	13.5 (11.6–15.8)	9.4 (8.1–11.0)	9.9 (8.5–11.5)	<0.001
Adjusted^b	14.7 (12.4–17.4)	14.9 (12.5–17.6)	10.7 (9.1–12.6)	11.2 (9.5–13.2)	0.001
Adjusted^b, additionally adjusted for nondense area^c	11.7 (9.9–13.7)	13.3 (11.3–15.7)	11.0 (9.5–12.9)	12.9 (11.1–15.1)	0.70
Adjusted^b, additionally adjusted for BMI^d	11.2 (9.4–13.3)	12.4 (10.4–14.9)	10.4 (8.8–12.3)	13.4 (11.3–15.9)	0.32
Adjusted^b, additionally adjusted for nondense area^c and BMI^d	10.7 (9.0–12.7)	12.2 (10.2–14.5)	10.4 (8.9–12.3)	13.3 (11.3–15.7)	0.16
Percent mammographic density (%)
Unadjusted	11.3 (9.8–12.9)	9.6 (8.3–11.0)	6.4 (5.5–7.3)	6.2 (5.4–7.2)	<0.001
Adjusted^b, and additionally adjusted for BMI^d	8.6 (7.3–10.0)	9.1(7.7–10.6)	7.6 (6.5–8.8)	9.7 (8.3–11.2)	0.58

^aMultiple linear regression. The absolute and percentage mammographic densities were log-transformed, reported means are back-transformed.
^bAdjusted for age (tertiles), full-term pregnancies (none, 1–2, 3, >3), age at first birth (<20 years, 20–24 years, >24 years) and postmenopausal hormone therapy (current use/noncurrent use).
^cNondense mammographic area (tertiles).
^dBody mass index (BMI), <20, 20–22, 23–24, 25–26, 27–28, 29–31, 32–34, >34.

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