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Table 3 Unadjusted and adjusted means of mammographic density (95% confidence interval) in quartiles of plasma leptin concentrationa (n = 967)

From: Plasma levels of leptin and mammographic density among postmenopausal women: a cross-sectional study

  Quartile of plasma leptin concentration P trend
  <9.1 ng/ml 9.1–14.5 ng/ml 14.6–24.0 ng/ml >24.0 ng/ml  
n 251 234 243 239  
Absolute mammographic density (cm2)      
   Unadjusted 13.8 (11.9–16.0) 13.5 (11.6–15.8) 9.4 (8.1–11.0) 9.9 (8.5–11.5) <0.001
   Adjustedb 14.7 (12.4–17.4) 14.9 (12.5–17.6) 10.7 (9.1–12.6) 11.2 (9.5–13.2) 0.001
   Adjustedb, additionally adjusted for nondense areac 11.7 (9.9–13.7) 13.3 (11.3–15.7) 11.0 (9.5–12.9) 12.9 (11.1–15.1) 0.70
   Adjustedb, additionally adjusted for BMId 11.2 (9.4–13.3) 12.4 (10.4–14.9) 10.4 (8.8–12.3) 13.4 (11.3–15.9) 0.32
   Adjustedb, additionally adjusted for nondense areac and BMId 10.7 (9.0–12.7) 12.2 (10.2–14.5) 10.4 (8.9–12.3) 13.3 (11.3–15.7) 0.16
Percent mammographic density (%)      
   Unadjusted 11.3 (9.8–12.9) 9.6 (8.3–11.0) 6.4 (5.5–7.3) 6.2 (5.4–7.2) <0.001
   Adjustedb, and additionally adjusted for BMId 8.6 (7.3–10.0) 9.1(7.7–10.6) 7.6 (6.5–8.8) 9.7 (8.3–11.2) 0.58
  1. aMultiple linear regression. The absolute and percentage mammographic densities were log-transformed, reported means are back-transformed.
  2. bAdjusted for age (tertiles), full-term pregnancies (none, 1–2, 3, >3), age at first birth (<20 years, 20–24 years, >24 years) and postmenopausal hormone therapy (current use/noncurrent use).
  3. cNondense mammographic area (tertiles).
  4. dBody mass index (BMI), <20, 20–22, 23–24, 25–26, 27–28, 29–31, 32–34, >34.