| ACS | EPIC | MEC | NHS | WHS | All | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls |
Number | 503 | 505 | 1,719 | 2,844 | 1,617 | 1,962 | 1,059 | 1,464 | 705 | 705 | 5,603 | 7,480 |
Mean age in years at blood donation (standard deviation) | 68.9 (5.9) | 68.9 (5.8) | 55.4 (7.9) | 55.1 (8.3) | 66.4 (8.6) | 63.6 (8.7) | 57.6 (7.0) | 58.2 (6.9) | 56.0 (7.3) | 56.0 (7.3) | 60.2 (9.4) | 59.0 (9.0) |
Mean body mass index (standard deviation) | 25.2 (4.6) | 25.5 (4.6) | 25.9 (4.4) | 26.1 (4.6) | 26.7 (5.6) | 27.0 (6.0) | 25.4 (4.7) | 25.6 (4.7) | 25.5 (4.4) | 26.0 (5.1) | 25.9 (4.9) | 26.2 (5.1) |
Age in years at menarche | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
≤12 | 46.9 | 45.3 | 35.5 | 36.2 | 53.9 | 49.7 | 42.4 | 48.7 | 56.7 | 51.6 | 47.8 | 44.3 |
13–14 | 43.9 | 46.7 | 48.5 | 45.5 | 35.5 | 38.6 | 39.5 | 42.9 | 37.0 | 42.7 | 41.1 | 43.0 |
15+ | 9.3 | 8.0 | 16.0 | 18.4 | 10.5 | 11.7 | 8.1 | 8.4 | 6.2 | 5.7 | 11.0 | 12.7 |
Menopausal status | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Premenopausal | 0 | 0 | 24.3 | 27.7 | 11.0 | 16.5 | 19.4 | 16.9 | 21.7 | 21.2 | 17.0 | 20.2 |
Postmenopausal | 100 | 100 | 67.1 | 63.6 | 86.5 | 81.8 | 71.3 | 74.8 | 63.5 | 60.2 | 76.0 | 72.7 |
Perimenopausal/unknown | 0 | 0 | 8.6 | 8.7 | 2.5 | 1.7 | 9.4 | 8.3 | 14.8 | 18.6 | 7.0 | 7.1 |
Age in years at menopause* | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
<40 | 10.2 | 9.9 | 4.5 | 5.0 | 16.3 | 18.9 | 9.9 | 11.1 | 7.1 | 9.0 | 10.6 | 11.4 |
40–44 | 10.2 | 12.4 | 9.5 | 10.3 | 14.9 | 16.9 | 12.2 | 11.3 | 10.0 | 14.5 | 12.0 | 13.1 |
45–49 | 20.4 | 28.2 | 28.9 | 31.8 | 26.6 | 27.9 | 27.6 | 28.1 | 31.1 | 31.6 | 27.0 | 29.4 |
50–54 | 46.6 | 39.7 | 47.1 | 44.0 | 32.8 | 29.0 | 44.5 | 43.7 | 43.9 | 36.8 | 41.3 | 38.4 |
55+ | 12.6 | 9.9 | 10.0 | 8.9 | 9.4 | 7.3 | 5.8 | 5.8 | 7.8 | 8.0 | 9.1 | 7.8 |
Parous women | 91.0 | 91.4 | 86.7 | 86.8 | 85.5 | 88.8 | 92.3 | 93.3 | 84.8 | 86.2 | 87.5 | 88.9 |
Family history | 20.7 | 15.5 | - | - | 17.1 | 11.1 | 19.2 | 13.9 | 20.1 | 16.3 | 18.6 | 13.3 |
Ever HRT use* | 67.0 | 58.7 | 42.3 | 34.1 | 63.9 | 58.9 | 77.2 | 72.0 | 68.0 | 60.3 | 61.4 | 53.5 |
Carcinoma in situ | 21.5 | - | 6.3 | - | 1.0 | - | 0 | - | 0 | - | 4.1 | - |
ER-positive | 52.7 | - | - | - | 62.0 | - | 68.0 | - | 80.4 | - | 65.8 | - |
PR-positive | 44.5 | - | - | - | 51.1 | - | 57.5 | - | 71.9 | - | 55.8 | - |
Ethnicity | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
White | 97.8 | 98.6 | 100 | 100 | 24.8 | 22.4 | 93.6 | 93.6 | 95.6 | 95.6 | 76.3 | 77.9 |
Hispanic | 0.8 | 0.2 | 0 | 0 | 20.8 | 19.7 | 0.1 | 0.3 | 0.6 | 0.6 | 6.2 | 5.3 |
African-American | 0.8 | 0.8 | 0 | 0 | 21.3 | 21.7 | 0.8 | 0.6 | 0.7 | 0.7 | 6.5 | 5.9 |
Asian | 0.4 | 0.4 | 0 | 0 | 26.3 | 21.4 | 0.1 | 0.4 | 1.0 | 1.0 | 7.8 | 5.8 |
Hawaiian | 0 | 0 | 0 | 0 | 6.7 | 14.8 | 0 | 0 | 0 | 0 | 2.0 | 3.9 |
Other | 0.2 | 0 | 0 | 0 | 0 | 0 | 5.5 | 5.1 | 2.1 | 2.1 | 1.3 | 1.2 |