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Table 3 Manganese superoxide dismutase -102 genotype: overall and recurrence-free survivals with radiation therapy

From: Association between manganese superoxide dismutase promoter gene polymorphism and breast cancer survival

Genotype Cases Deaths Hazard ratio minimally adjusteda (95% confidence interval) Hazard ratio fully adjustedb (95% confidence interval)
Overall survival 150 33 P for trend = 0.67 P for trend = 0.91
   CC 93 20 1 (reference) 1 (reference)
   CT 51 11 0.97 (0.46–2.04) 0.74 (0.35–1.58)
   TT 6 2 1.95 (0.45–8.49) 2.23 (0.46–10.79)
   CC 93 20 1 (reference) 1 (reference)
   CT + TT 57 13 1.05 (0.52–2.12) 0.82 (0.40–1.70)
Recurrence-free survival 145 40 P for trend = 0.14 P for trend = 0.03
   CC 90 29 1 (reference) 1 (reference)
   CT 50 10 0.57 (0.28–1.18) 0.40 (0.18–0.86)
   TT 5 1 0.60 (0.08–4.47) 0.69 (0.09–5.46)
   CC 90 29 1 (reference) 1 (reference)
   CT + TT 55 11 0.57 (0.28–1.16) 0.42 (0.20–0.87)
  1. CC, homozygous for the wild-type manganese superoxide dismutase gene; CT, heterozygous for the variant genotype; TT, homozygous for the variant genotype. aMinimally adjusted model: age. bFully adjusted model: age, stage with node status at diagnosis, race, estrogen receptor status, and progesterone receptor status.