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Table 2 Manganese superoxide dismutase -102 genotype: overall and recurrence-free survivals

From: Association between manganese superoxide dismutase promoter gene polymorphism and breast cancer survival

Genotype Cases Deaths Hazard ratio minimally adjusteda (95% confidence interval) Hazard ratio fully adjustedb (95% confidence interval)
Overall survival 291 85 P for trend = 0.62 P for trend = 0.88
   CC 180 55 1 (reference) 1 (reference)
   CT 92 25 0.89 (0.55–1.43) 0.75 (0.465–1.24)
   TT 19 5 0.88 (0.35–2.20) 1.06 (0.42–2.69)
   CC 180 55 1 (reference) 1 (reference)
   CT + TT 111 30 0.89 (0.57–1.38) 0.80 (0.50–1.28)
Recurrence-free survival 280c 100 P for trend = 0.12 P for trend = 0.08
   CC 175 68 1 (reference) 1 (reference)
   CT 87 28 0.77 (0.50–1.20) 0.65 (0.41–1.04)
   TT 18 4 0.55 (0.20–1.50) 0.66 (0.24–1.83)
   CC 175 68 1 (reference) 1 (reference)
   CT + TT 105 32 0.73 (0.48–1.12) 0.65 (0.42–1.01)
  1. CC, homozygous for the wild-type manganese superoxide dismutase gene; CT, heterozygous for the variant genotype; TT, homozygous for the variant genotype. aMinimally adjusted model: age. bFully adjusted model: age, stage with node status at diagnosis, race, estrogen receptor status, and progesterone receptor status. cEleven subjects were never disease free, thus they were deleted for recurrence-free survival.