Association between manganese superoxide dismutase promoter gene polymorphism and breast cancer survival

Breast Cancer Research

Table 2 Manganese superoxide dismutase -102 genotype: overall and recurrence-free survivals

Genotype	Cases	Deaths	Hazard ratio minimally adjusted^a (95% confidence interval)	Hazard ratio fully adjusted^b (95% confidence interval)
Overall survival	291	85	P for trend = 0.62	P for trend = 0.88
CC	180	55	1 (reference)	1 (reference)
CT	92	25	0.89 (0.55–1.43)	0.75 (0.465–1.24)
TT	19	5	0.88 (0.35–2.20)	1.06 (0.42–2.69)
CC	180	55	1 (reference)	1 (reference)
CT + TT	111	30	0.89 (0.57–1.38)	0.80 (0.50–1.28)
Recurrence-free survival	280^c	100	P for trend = 0.12	P for trend = 0.08
CC	175	68	1 (reference)	1 (reference)
CT	87	28	0.77 (0.50–1.20)	0.65 (0.41–1.04)
TT	18	4	0.55 (0.20–1.50)	0.66 (0.24–1.83)
CC	175	68	1 (reference)	1 (reference)
CT + TT	105	32	0.73 (0.48–1.12)	0.65 (0.42–1.01)

CC, homozygous for the wild-type manganese superoxide dismutase gene; CT, heterozygous for the variant genotype; TT, homozygous for the variant genotype. ^aMinimally adjusted model: age. ^bFully adjusted model: age, stage with node status at diagnosis, race, estrogen receptor status, and progesterone receptor status. ^cEleven subjects were never disease free, thus they were deleted for recurrence-free survival.

ISSN: 1465-542X