Prognostic variable | Univariate | Multivariate | ||||
---|---|---|---|---|---|---|
 | RR | 95% CI | p | RR | 95% CI | p |
Previous IBTR (yes versus else) | 3.04 | 1.72–5.35 | 0.0001 | 2.58 | 1.41–4.72 | 0.002 |
Age at primary diagnosisa | 1.17 | 0.64–2.13 | 0.61 | 0.79 | 0.42–1.46 | 0.45 |
Intraductal (yes versus else) | 0.90 | 0.62–1.29 | 0.56 |  |  |  |
Multicentricity (yes versus else) | 1.01 | 0.49–2.08 | 0.97 |  |  |  |
Histological grade | Â | Â | Â | Â | Â | Â |
   'G2' and G3 versus G1 | 14.64 | 3.64–58.9 | 0.006 | 8.59 | 2.09–35.36 | 0.003 |
   Not done and don't know versus G1 | 7.86 | 1.81–34.2 | 0.0002 | 4.73 | 1.07–20.94 | 0.04 |
Tumour size | Â | Â | Â | Â | Â | Â |
   1–2 cm versus <1 cm | 2.74 | 1.49–5.03 | 0.001 | 1.95 | 1.05–3.64 | 0.04 |
   >2 cm versus <1 cm | 4.97 | 2.71–9.12 | < 0.00001 | 2.94 | 1.56–5.56 | 0.0009 |
Oestrogen receptor statusb | 2.77 | 1.91–4.01 | < 0.00001 | 1.23 | 0.75–2.04 | 0.41 |
Progesterone receptor statusb | 3.56 | 2.47–5.14 | < 0.00001 | 2.15 | 1.36–3.39 | 0.001 |
Menopausal statusc | 1.18 | 0.81–1.72 | 0.38 |  |  |  |
Vascular invasion (yes versus else) | 1.78 | 0.83–3.83 | 0.14 |  |  |  |
Lymphatic invasion (yes versus else) | 2.35 | 1.55–3.57 | 0.00006 | 1.78 | 1.17–2.72 | 0.008 |
Radiation therapy versus none | 1.19 | 0.70–2.01 | 0.53 | 1.18 | 0.67–2.09 | 0.57 |
Adjuvant treatment | Â | Â | Â | Â | Â | Â |
   Hormone therapy versus none | 0.66 | 0.46–0.97 | 0.03 | 0.75 | 0.50–1.15 | 0.19 |
   Chemotherapy versus none | 1.47 | 0.92–2.36 | 0.11 | 0.62 | 0.36–1.05 | 0.07 |