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Table 3 Results of disease-specific survival analysis by univariate and multivariate Cox proportional hazards models

From: Analysis of incidence and prognostic factors for ipsilateral breast tumour recurrence and its impact on disease-specific survival of women with node-negative breast cancer: a prospective cohort study

Prognostic variable

Univariate

Multivariate

 

RR

95% CI

p

RR

95% CI

p

Previous IBTR (yes versus else)

3.04

1.72–5.35

0.0001

2.58

1.41–4.72

0.002

Age at primary diagnosisa

1.17

0.64–2.13

0.61

0.79

0.42–1.46

0.45

Intraductal (yes versus else)

0.90

0.62–1.29

0.56

   

Multicentricity (yes versus else)

1.01

0.49–2.08

0.97

   

Histological grade

      

   'G2' and G3 versus G1

14.64

3.64–58.9

0.006

8.59

2.09–35.36

0.003

   Not done and don't know versus G1

7.86

1.81–34.2

0.0002

4.73

1.07–20.94

0.04

Tumour size

      

   1–2 cm versus <1 cm

2.74

1.49–5.03

0.001

1.95

1.05–3.64

0.04

   >2 cm versus <1 cm

4.97

2.71–9.12

< 0.00001

2.94

1.56–5.56

0.0009

Oestrogen receptor statusb

2.77

1.91–4.01

< 0.00001

1.23

0.75–2.04

0.41

Progesterone receptor statusb

3.56

2.47–5.14

< 0.00001

2.15

1.36–3.39

0.001

Menopausal statusc

1.18

0.81–1.72

0.38

   

Vascular invasion (yes versus else)

1.78

0.83–3.83

0.14

   

Lymphatic invasion (yes versus else)

2.35

1.55–3.57

0.00006

1.78

1.17–2.72

0.008

Radiation therapy versus none

1.19

0.70–2.01

0.53

1.18

0.67–2.09

0.57

Adjuvant treatment

      

   Hormone therapy versus none

0.66

0.46–0.97

0.03

0.75

0.50–1.15

0.19

   Chemotherapy versus none

1.47

0.92–2.36

0.11

0.62

0.36–1.05

0.07

  1. 117 deaths from or with disease among 1,540 eligible women. CI, confidence interval; IBTR, ipsilateral breast tumour recurrence; RR, relative risk. aAge < 40 years versus age ≥ 40 years; bnegative and equivocal versus positive and don't know and not done; cpremenopausal and perimenopausal aged < 50 years versus postmenopausal and perimenopausal aged ≥ 50 years.