Mouse models of breast cancer metastasis

Fantozzi, Anna; Christofori, Gerhard

doi:10.1186/bcr1530

Breast Cancer Research

Table 2 Transgenic mouse models of breast cancer metastasis

From: Mouse models of breast cancer metastasis

TG mouse model	Expression	Tumor incidence (%)	Tumor latency (months)	Metastasis incidence (%)	Metastatic site	Metastasis latency (months)	References
Single-transgenic mice
MMTV-Cox2	Mammary gland	>85	7^a	b	LN		[101]
MMTV-Wnt1	Mammary gland	60	8	b	Lung, LN		[7,16,77]
MMTV-Neu	Mammary gland	100	6.8^a	72	Lung	8	[16,102]
MMTV-Neu activated	Mammary gland	100	3^a-5	20	Lung	3.5	[42,44]
MMTV-Neu (YB)	Mammary gland	100	6^a	65	Lung	2	[44,67]
MMTV-Neu (YD)	Mammary gland	100	3.6^a	44	Lung	2
MMTV-PyMT	Mammary gland	100	1–6	>85; 51	Lung; LN	3.5	[16,45,51]
MTB-TAN	Mammary gland	100	-	92	Lung		[16,103]
MT-Met	Mammary gland	b	10	b	Lung; LN; kidney; heart; cecum		[16,104]
C3(1)-Tag	Mammary gland	100	3–6	b	Lung		[16,105]
Wap-Notch4	Mammary gland	100	6.2	High	Lung		[106]
Wap-T-NP	Mammary gland	12–83	11	b	Lung, LN		[107]
Wap-Ras	Mammary gland, salivary gland	100	6	14	Lung		[16,108]
Wap-HGF	Mammary gland	89	1–2	22	Lung	1–2	[109]
H19-IGF2	Mammary gland	50–100	>9	38	Lung, spleen; liver		[16,110]
Composite-transgenic mice
p53fp/fp MMTV-Cre Wap-Cre	Mammary gland deletion	100	10–18^a	50	Lung, liver		[111]
p53^+/- MMTV-ΔN-β-catenin	Mammary gland	100	9.8^a	39	Lung		[112]
CD44^-/-MMTV-PyMT	Mammary gland	100	3.5^a	66	Lung	3.5	[12]
MMTV-Neu;SR2F	Mammary gland	86.8	8^a	12	Lung		[70]
MMTV-NeuYB;TβRI(AAD)	Mammary gland		8.9^a	65	Lung	2	[67]
MMTV-NeuYD;TβRI(AAD)	Mammary gland		4.4^a	44	>Extravascular
MMTV-NeuYB;TβRII(ΔCyt)	Mammary gland		6^a	65	<Extravascular
MMTV-rtTA/TetOp-TGF-β1S223/225; MMTV-PyMT	Mammary gland		1.8^a	>10-fold	Lung	3.2	[68]
MMTV-Neu; S100A4	Mammary gland		12	50	Lung		[16,113]
MMTV-Wnt1; int2	Mammary gland	90	4^a	b	Lung, LN		[7,77]
MMTV-PyMT; uPA^-/-	Mammary gland	100	1.5^a	31	Lung, LN	3.5	[45,51,52]
MMTV-PyMT; Plg^-/-	Mammary gland	100	1.5^a	25^c	Lung	3
MMTV-PyMT; VEGF	Mammary gland	100	1–2	100	Lung	2	[91]
MMTV-PyMT; MEKK1^-/-	Mammary gland	100	3	25	Lung	4	[53]

^aTumor t ₅₀ was reported; ^bmetastasis/tumor appearance but not incidence was reported; ^clung metastasis in all Plg^-/- mice analyzed versus 56% in control mice; metastasis was dependent on tumor burden. HGF, hepatocyte growth factor; LN, lymph nodes.

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ISSN: 1465-542X

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