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Table 2 Transgenic mouse models of breast cancer metastasis

From: Mouse models of breast cancer metastasis

TG mouse model Expression Tumor incidence (%) Tumor latency (months) Metastasis incidence (%) Metastatic site Metastasis latency (months) References
Single-transgenic mice        
   MMTV-Cox2 Mammary gland >85 7a b LN   [101]
   MMTV-Wnt1 Mammary gland 60 8 b Lung, LN   [7,16,77]
   MMTV-Neu Mammary gland 100 6.8a 72 Lung 8 [16,102]
   MMTV-Neu activated Mammary gland 100 3a-5 20 Lung 3.5 [42,44]
   MMTV-Neu (YB) Mammary gland 100 6a 65 Lung 2 [44,67]
   MMTV-Neu (YD) Mammary gland 100 3.6a 44 Lung 2  
   MMTV-PyMT Mammary gland 100 1–6 >85; 51 Lung; LN 3.5 [16,45,51]
   MTB-TAN Mammary gland 100 - 92 Lung   [16,103]
   MT-Met Mammary gland b 10 b Lung; LN; kidney; heart; cecum   [16,104]
   C3(1)-Tag Mammary gland 100 3–6 b Lung   [16,105]
   Wap-Notch4 Mammary gland 100 6.2 High Lung   [106]
   Wap-T-NP Mammary gland 12–83 11 b Lung, LN   [107]
   Wap-Ras Mammary gland, salivary gland 100 6 14 Lung   [16,108]
   Wap-HGF Mammary gland 89 1–2 22 Lung 1–2 [109]
   H19-IGF2 Mammary gland 50–100 >9 38 Lung, spleen; liver   [16,110]
Composite-transgenic mice        
   p53fp/fp MMTV-Cre Wap-Cre Mammary gland deletion 100 10–18a 50 Lung, liver   [111]
   p53+/- MMTV-ΔN-β-catenin Mammary gland 100 9.8a 39 Lung   [112]
   CD44-/-MMTV-PyMT Mammary gland 100 3.5a 66 Lung 3.5 [12]
   MMTV-Neu;SR2F Mammary gland 86.8 8a 12 Lung   [70]
   MMTV-NeuYB;TβRI(AAD) Mammary gland   8.9a 65 Lung 2 [67]
   MMTV-NeuYD;TβRI(AAD) Mammary gland   4.4a 44 >Extravascular   
   MMTV-NeuYB;TβRII(ΔCyt) Mammary gland   6a 65 <Extravascular   
   MMTV-rtTA/TetOp-TGF-β1S223/225; MMTV-PyMT Mammary gland   1.8a >10-fold Lung 3.2 [68]
   MMTV-Neu; S100A4 Mammary gland   12 50 Lung   [16,113]
   MMTV-Wnt1; int2 Mammary gland 90 4a b Lung, LN   [7,77]
   MMTV-PyMT; uPA-/- Mammary gland 100 1.5a 31 Lung, LN 3.5 [45,51,52]
   MMTV-PyMT; Plg-/- Mammary gland 100 1.5a 25c Lung 3  
   MMTV-PyMT; VEGF Mammary gland 100 1–2 100 Lung 2 [91]
   MMTV-PyMT; MEKK1-/- Mammary gland 100 3 25 Lung 4 [53]
  1. aTumor t 50 was reported; bmetastasis/tumor appearance but not incidence was reported; clung metastasis in all Plg-/- mice analyzed versus 56% in control mice; metastasis was dependent on tumor burden. HGF, hepatocyte growth factor; LN, lymph nodes.