Table 2 Phenotypic features of the BRCA1 methylated tumors
From: Epigenetic silencing and deletion of the BRCA1gene in sporadic breast cancer
Tumour number | AI at BRCA1 | AI at BRCA2 | TP53 mutation | ER status | PR status | BRCA1 protein expressiona | DNA index | Interpretation of FISH |
1 | + | - | - | + | + | 1 | NA | Deletion of the BRCA1 region |
2 | + | - | - | - | - | 1 | 1.68 | Deletion of the BRCA1 region |
3 | + | + | + | - | - | 1 | 1.12; 1.99 | Chromosome 17 deletion |
4 | + | + | + | - | - | 1 | 1.54 | Chromosome 17 deletion |
5 | + | + | + | + | + | 1 | 1.22; 2.18 | Chromosome 17 deletion |
6 | - | - | - | + | + | 1 | NA | Chromosome 17 deletion |
7 | + | - | + | - | - | 1 | 3.32 | No detectable BRCA1 deletion |
8 | - | - | - | + | + | 1 | 1.11; 1.80 | No detectable BRCA1 deletion |
9 | + | + | + | - | - | 1 | 1.00 | No detectable BRCA1 deletion |
10 | - | - | - | + | + | 2 | 1.69 | No detectable BRCA1 deletion |
11 | - | - | - | - | - | 3 | 1.00 | No detectable BRCA1 deletion |
12 | - | - | - | + | + | 3 | 2.09 | No detectable BRCA1 deletion |
13 | + | + | - | - | NA | 3 | NA | No detectable BRCA1 deletion |