Figure 2
From: Epigenetic silencing and deletion of the BRCA1gene in sporadic breast cancer
Allelic imbalance analysis at the BRCA loci. The electropherograms represent quantification of PCR products from normal DNA (upper) and tumour DNA (lower) from the same individual. A signal reduction is evident in the tumour electropherograms, which suggest allelic imbalance (indicated by an arrow) at the (a) BRCA1 locus, using the D17S1323 marker, and (b) BRCA2 locus, using the D13S260 marker.